Медицинская библиотека · Nature · 2019

Conserved cell types with divergent features in human versus mouse cortex.

Hodge Rebecca D, Bakken Trygve E, Miller Jeremy A, Smith Kimberly A, Barkan Eliza R, Graybuck Lucas T, Close Jennie L, Long Brian, Johansen Nelson, Penn Osnat, Yao Zizhen, Eggermont Jeroen, Höllt Thomas, Levi Boaz P, Shehata Soraya I, Aevermann Brian, Beller Allison, Bertagnolli Darren, Brouner Krissy, Casper Tamara, Cobbs Charles, Dalley Rachel, Dee Nick, Ding Song-Lin, Ellenbogen Richard G, Fong Olivia, Garren Emma, Goldy Jeff, Gwinn Ryder P, Hirschstein Daniel, Keene C Dirk, Keshk Mohamed, Ko Andrew L, Lathia Kanan, Mahfouz Ahmed, Maltzer Zoe, McGraw Medea, Nguyen Thuc Nghi, Nyhus Julie, Ojemann Jeffrey G, Oldre Aaron, Parry Sheana, Reynolds Shannon, Rimorin Christine, Shapovalova Nadiya V, Somasundaram Saroja, Szafer Aaron, Thomsen Elliot R, Tieu Michael, Quon Gerald, Scheuermann Richard H, Yuste Rafael, Sunkin Susan M, Lelieveldt Boudewijn, Feng David, Ng Lydia, Bernard Amy, Hawrylycz Michael, Phillips John W, Tasic Bosiljka, Zeng Hongkui, Jones Allan R, Koch Christof, Lein Ed S

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Elucidating the cellular architecture of the human cerebral cortex is central to understanding our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA-sequencing analysis to perform a comprehensive study of cell types in the middle temporal gyrus of human cortex. We identified a highly diverse set of excitatory and inhibitory neuron types that are mostly sparse, with excitatory types being less layer-restricted than expected. Comparison to similar mouse cortex single-cell RNA-sequencing datasets revealed a surprisingly well-conserved cellular architecture that enables matching of homologous types and predictions of properties of human cell types. Despite this general conservation, we also found extensive differences between homologous human and mouse cell types, including marked alterations in proportions, laminar distributions, gene expression and morphology. These species-specific features emphasize the importance of directly studying human brain.

Для цитирования: Hodge Rebecca D, Bakken Trygve E, Miller Jeremy A, Smith Kimberly A, Barkan Eliza R, Graybuck Lucas T, Close Jennie L, Long Brian, Johansen Nelson, Penn Osnat, Yao Zizhen, Eggermont Jeroen, Höllt Thomas, Levi Boaz P, Shehata Soraya I, Aevermann Brian, Beller Allison, Bertagnolli Darren, Brouner Krissy, Casper Tamara, Cobbs Charles, Dalley Rachel, Dee Nick, Ding Song-Lin, Ellenbogen Richard G, Fong Olivia, Garren Emma, Goldy Jeff, Gwinn Ryder P, Hirschstein Daniel, Keene C Dirk, Keshk Mohamed, Ko Andrew L, Lathia Kanan, Mahfouz Ahmed, Maltzer Zoe, McGraw Medea, Nguyen Thuc Nghi, Nyhus Julie, Ojemann Jeffrey G, Oldre Aaron, Parry Sheana, Reynolds Shannon, Rimorin Christine, Shapovalova Nadiya V, Somasundaram Saroja, Szafer Aaron, Thomsen Elliot R, Tieu Michael, Quon Gerald, Scheuermann Richard H, Yuste Rafael, Sunkin Susan M, Lelieveldt Boudewijn, Feng David, Ng Lydia, Bernard Amy, Hawrylycz Michael, Phillips John W, Tasic Bosiljka, Zeng Hongkui, Jones Allan R, Koch Christof, Lein Ed S. Conserved cell types with divergent features in human versus mouse cortex.. Nature. 2019. DOI: 10.1038/s41586-019-1506-7.

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