Pathogenesis and targets in uveitis.

Uveitis is the most common ocular finding in systemic rheumatic diseases. It is a potentially sight threatening disease seen on its own or in association with systemic rheumatic diseases. Whilst significant advances have been made with biological and small molecular therapies for conditions such as rheumatoid arthritis (RA), ankylosing spondylisitis (AS), juvenile idiopathic arthritis (JIA) and psoriatic arthritis (PsA), the evidence base for managing the ocular complications from these diseases, particularly uveitis, is still limited.