Use of antimicrobial photodynamic therapy and high-power Er:YAG laser in the treatment of drug- or radiation-induced bone necrosis: Case series.

Osteoradionecrosis (ORN) and medication-related osteonecrosis of the jaws (MRONJ) are debilitating complications that compromise bone repair in patients, who have undergone radiotherapy or treatment with anti-resorptive/anti-angiogenic drugs. Once established, these lesions are difficult to manage and reduce patients' quality of life. The combination of low- and high-power lasers, through photo biomodulation therapy and antimicrobial photodynamic therapy preceding surgical laser debridement, can provide satisfactory results in the treatment of these patients. Thus, the purpose of this work is to describe three cases associating these therapies for the management and treatment of ORN and ONMRM, offering an alternative, safe and effective therapy for these conditions.