European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
Length of mobile phone use mediating the effect of major depression on low back pain/sciatica: a mendelian randomization study.
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Liu Wangmi, Zhang Xiaxuan, Wang Yuejian, Chen Dechao, Zhao Kongjun, Liang Jianjun
Аннотация
PURPOSE: Accumulating evidence indicates an association between major depression (MD) and the occurrence of low back pain/sciatica (LBP/S). In order to examine this association, we conducted a Mendelian randomization (MR) study, further evaluating the extent to which the length of mobile phone use mediates the impact of MD on the risk of developing LBP/S.
METHODS: Genetic instruments and association estimates for MD, LBP/S, and length of mobile phone use were extracted from existing Genome-wide Association Study (GWAS) summary data. Bidirectional two-sample MR analyses were conducted to investigate the influence of MD on the risk of LBP/S. Furthermore, MR mediation analyses were executed to evaluate whether the length of mobile phone use mediates any effect of MD on LBP/S.
RESULTS: MR analyses showed that a higher genetic risk for MD increased the odds of LBP/S (odds ratio [OR] 1.241; 95% confidence interval [CI], 1.065-1.446). The mediation analysis, employing a two-step MR approach, indicated that the observed effect was partially mediated by the length of mobile phone use, accounting for a mediated proportion of 12.0% (95% CI, 2.3-25.0%).
CONCLUSION: These findings may serve as a foundation for devising preventive strategies and interventions aimed at regulating the length of mobile phone use for individuals grappling with LBP/S in the context of MD.
METHODS: Genetic instruments and association estimates for MD, LBP/S, and length of mobile phone use were extracted from existing Genome-wide Association Study (GWAS) summary data. Bidirectional two-sample MR analyses were conducted to investigate the influence of MD on the risk of LBP/S. Furthermore, MR mediation analyses were executed to evaluate whether the length of mobile phone use mediates any effect of MD on LBP/S.
RESULTS: MR analyses showed that a higher genetic risk for MD increased the odds of LBP/S (odds ratio [OR] 1.241; 95% confidence interval [CI], 1.065-1.446). The mediation analysis, employing a two-step MR approach, indicated that the observed effect was partially mediated by the length of mobile phone use, accounting for a mediated proportion of 12.0% (95% CI, 2.3-25.0%).
CONCLUSION: These findings may serve as a foundation for devising preventive strategies and interventions aimed at regulating the length of mobile phone use for individuals grappling with LBP/S in the context of MD.