Cardiovascular & hematological disorders drug targets · 2026
Relationship Between Triglyceride Glucose Index and Right Ventricular Dysfunction in Chronic Obstructive Pulmonary Disease.
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Akab Samah M, Shoman Heba, ElBazzar Noran, Mansour Ahmed, Abd El-Kareem Shimaa Mohamed, El Gharib Hend O, Hossam-Eldin Gehan E, Elbakery Mohamed AbdElrahman AbdElkader, Mohamed Suzan Mohamed Abdel Kareem, Abozaid Sarah Y, A M Abdul-Mohymen, Yehia Fatima G, Moazen Eman M, Elfeky Seham Ezzat Fathy
Аннотация
INTRODUCTION: The present study aimed to assess the relationship between the triglyceride glucose (TyG) index and early right ventricular dysfunction (RVD) in patients with chronic obstructive pulmonary disease (COPD).
METHODS: The study included 100 patients with COPD and 50 age and sex-matched healthy controls. All patients were subjected to careful history taking and thorough general, chest, and cardiac examinations. Patients' symptoms were evaluated using the modified Medical Research Council (mMRC) dyspnea scale and the COPD Assessment Test (CAT). All images of the right heart were obtained using a GE Vivid 7 with a 3S transducer (1.5-3.6 MHz). Tricuspid annular plane systolic excursion (TAPSE) was calculated by measuring the distance of the RV annular segment's systolic excursion along its longitudinal plane from a conventional apical 4-chamber window. TAPSE < 17 indicated RVD.
RESULTS: Patients were found to have a significantly higher TyG index compared to controls (4.86 ± 0.09 versus 4.54 ± 0.1, p <0.001). According to echocardiographic findings, there were 33 patients with RVD. Multivariate logistic regression analysis identified patients' age [OR (95% CI): 1.66 (1.45-1.97), p =0.034], disease duration [OR (95% CI): 2.07 (1.06-4.06), p =0.035], COPD severity [OR (95% CI): 7.71 (1.23-48.12), p =0.041] and TyG index [OR (95% CI): 4.13 (1.02-16.74), p =0.047] as predictors of RVD.
CONCLUSION: In patients with COPD, early RVD is related to the TyG index. This finding emphasizes the importance of biometabolic factors in the pathogenesis and management of COPD.
METHODS: The study included 100 patients with COPD and 50 age and sex-matched healthy controls. All patients were subjected to careful history taking and thorough general, chest, and cardiac examinations. Patients' symptoms were evaluated using the modified Medical Research Council (mMRC) dyspnea scale and the COPD Assessment Test (CAT). All images of the right heart were obtained using a GE Vivid 7 with a 3S transducer (1.5-3.6 MHz). Tricuspid annular plane systolic excursion (TAPSE) was calculated by measuring the distance of the RV annular segment's systolic excursion along its longitudinal plane from a conventional apical 4-chamber window. TAPSE < 17 indicated RVD.
RESULTS: Patients were found to have a significantly higher TyG index compared to controls (4.86 ± 0.09 versus 4.54 ± 0.1, p <0.001). According to echocardiographic findings, there were 33 patients with RVD. Multivariate logistic regression analysis identified patients' age [OR (95% CI): 1.66 (1.45-1.97), p =0.034], disease duration [OR (95% CI): 2.07 (1.06-4.06), p =0.035], COPD severity [OR (95% CI): 7.71 (1.23-48.12), p =0.041] and TyG index [OR (95% CI): 4.13 (1.02-16.74), p =0.047] as predictors of RVD.
CONCLUSION: In patients with COPD, early RVD is related to the TyG index. This finding emphasizes the importance of biometabolic factors in the pathogenesis and management of COPD.