Impact of EMG-based interfaces for hand motor rehabilitation in stroke: A systematic review with evidence gap map and meta-analysis.

Electromyography (EMG)-based interventions have been proposed to improve hand/wrist motor recovery after stroke; however, their clinical value remains uncertain, as evidence for their effectiveness is inconsistent. This systematic review with meta-analysis evaluated the impact of different EMG-based rehabilitation approaches compared with non-EMG-based interventions in individuals with stroke. Seven databases were searched from inception to November 17, 2025, in accordance with PRISMA guidelines. Randomized controlled trials comparing EMG-based and non-EMG-based interventions for post-stroke hand or wrist rehabilitation were eligible. Interventions were classified into four categories: EMG-triggered electrical stimulation (EMG-ES), EMG-ES combined with other interventions, EMG-based robotic platforms, and EMG biofeedback combined with other interventions. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool, and certainty of evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Meta-analyses were conducted for clinical outcomes classified according to the International Classification of Functioning, Disability and Health (ICF) domains at post-intervention, follow-up <3 months, and follow-up ≥3 months. Thirty-eight studies involving 1,132 participants were included, of which 31 contributed to the meta-analyses. Eight studies were judged to have a low risk of bias, 13 to have some concerns, and 17 to have a high risk of bias. EMG-ES alone was not superior to conventional therapy. In contrast, EMG-ES combined with other interventions produced greater improvements across all ICF domains. EMG-based robotic platforms reduced wrist and finger spasticity, with effects sustained at long-term follow-up. EMG biofeedback primarily improved outcomes within the ICF body functions and structures domain. The effectiveness of EMG-based interventions depends on the rehabilitation strategy. EMG-ES, combined with other therapies, may be prioritized, whereas EMG-based robotic platforms may be useful in reducing spasticity. Further high-quality studies are needed to establish the clinical effectiveness of EMG-biofeedback approaches.