MedElevator
Войти в исследования Arthritis care & research · 2026
Association of Vaccination With COVID Outcomes in Pregnant People With Autoimmune Diseases: A Retrospective National Cohort Analysis.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Jaferian Sohrab, Wilkins Kenneth, Qin Qiuyuan, Anzalone A Jerrod, Lind Margaret L, Sutton Anna, Hill Elaine L, Patel Rena C, Singh Namrata, National Clinical Cohort Collaborative (N3C)
Аннотация
OBJECTIVE: To evaluate the effectiveness of COVID-19 vaccination in reducing incident and severe COVID-19 among pregnant individuals with autoimmune rheumatic diseases (AIRDs).
METHODS: We conducted a retrospective cohort study using national electronic health records, including 270,811 pregnant individuals aged 15 to 55 years with pregnancies between December 10, 2020, and June 1, 2024. Among them, 4,715 (1.5%) had at least one AIRD (rheumatoid arthritis, spondyloarthritis, or systemic lupus erythematosus). Participants were categorized by AIRD and vaccination status (unvaccinated, initially vaccinated, or booster vaccinated). Time to incident and severe COVID-19 was assessed using adjusted time ratios (TRs), stratified by variant period (pre-Omicron vs Omicron).
RESULTS: Initial vaccination delayed time to COVID-19 during the pre-Omicron period in individuals with AIRDs (TR: 1.095; 95% confidence interval [CI]: 1.036-1.157) but not during Omicron (TR: 1.039; 95% CI: 0.980-1.102). Booster vaccination was not significantly protective against infection (TR: 1.039; 95% CI: 0.958-1.128) or severe outcomes (TR: 1.119; 95% CI: 0.670-1.867). Compared to vaccinated individuals without AIRDs, those with AIRDs had shorter time to breakthrough infections in both pre-Omicron (TR: 0.940; 95% CI: 0.891-0.991) and Omicron (TR: 0.905; 95% CI: 0.858-0.955) periods and to severe disease during Omicron (TR: 0.631; 95% CI: 0.485-0.821).
CONCLUSION: Vaccination is associated with protection against COVID-19 in pregnancy, but its effectiveness is reduced in those with AIRDs, particularly during the Omicron period.
METHODS: We conducted a retrospective cohort study using national electronic health records, including 270,811 pregnant individuals aged 15 to 55 years with pregnancies between December 10, 2020, and June 1, 2024. Among them, 4,715 (1.5%) had at least one AIRD (rheumatoid arthritis, spondyloarthritis, or systemic lupus erythematosus). Participants were categorized by AIRD and vaccination status (unvaccinated, initially vaccinated, or booster vaccinated). Time to incident and severe COVID-19 was assessed using adjusted time ratios (TRs), stratified by variant period (pre-Omicron vs Omicron).
RESULTS: Initial vaccination delayed time to COVID-19 during the pre-Omicron period in individuals with AIRDs (TR: 1.095; 95% confidence interval [CI]: 1.036-1.157) but not during Omicron (TR: 1.039; 95% CI: 0.980-1.102). Booster vaccination was not significantly protective against infection (TR: 1.039; 95% CI: 0.958-1.128) or severe outcomes (TR: 1.119; 95% CI: 0.670-1.867). Compared to vaccinated individuals without AIRDs, those with AIRDs had shorter time to breakthrough infections in both pre-Omicron (TR: 0.940; 95% CI: 0.891-0.991) and Omicron (TR: 0.905; 95% CI: 0.858-0.955) periods and to severe disease during Omicron (TR: 0.631; 95% CI: 0.485-0.821).
CONCLUSION: Vaccination is associated with protection against COVID-19 in pregnancy, but its effectiveness is reduced in those with AIRDs, particularly during the Omicron period.