ERJ open research · 2026
Comparison of airway mucin 5AC and 5B expression in preterm-born adults and asthma.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kreus Mervi, Um-Bergström Petra, Merikallio Heta, Lappi-Blanco Elisa, Miinalainen Ilkka, Wagner Nicole Y, Berggren-Broström Eva, Melén Erik, Lindén Anders, Wheelock Åsa M, Kaarteenaho Riitta, Sköld C Magnus
Аннотация
BACKGROUND: As preterm birth is a risk factor for developing chronic lung disease later in life and has been associated with asthma-like symptoms, we hypothesised that preterm-born adults with and without a history of bronchopulmonary dysplasia (BPD) resemble patients with asthma with respect to altered mucin expression in the airways.
METHODS: Bronchial biopsies were retrieved from 39 adults born very-to-extremely preterm (of which 22 had a history of BPD), 18 adults with mild allergic asthma and 24 healthy controls. Mucin (MUC) 5AC and MUC5B protein expressions were determined by immunohistochemistry and immunoelectron microscopy. Additionally, the percentage of goblet cells was estimated.
RESULTS: MUC5AC expression and the percentage of goblet cells were lower in preterm-born adults than in asthma patients but did not markedly differ from those of healthy controls. In the preterm-born adults, MUC5AC expression correlated negatively with forced expiratory volume in 1 s to forced vital capacity ratio (FEV1/FVC) and positively with St George's Respiratory Questionnaire scores. Preterm-born adults with high MUC5AC expression had more bronchial hyperreactivity than those with low expression. MUC5B expression was lower in preterm-born adults with bronchial hyperreactivity and higher in those who reported having phlegm compared with those who did not have these signs.
CONCLUSIONS: Unlike patients with asthma, preterm-born adults with or without BPD do not exhibit increased MUC5AC expression compared with healthy controls. However, the associations of MUC5AC and MUC5B expression with lung function, symptoms and quality-of-life indices suggest a potential clinical role for these mucins in this population.
METHODS: Bronchial biopsies were retrieved from 39 adults born very-to-extremely preterm (of which 22 had a history of BPD), 18 adults with mild allergic asthma and 24 healthy controls. Mucin (MUC) 5AC and MUC5B protein expressions were determined by immunohistochemistry and immunoelectron microscopy. Additionally, the percentage of goblet cells was estimated.
RESULTS: MUC5AC expression and the percentage of goblet cells were lower in preterm-born adults than in asthma patients but did not markedly differ from those of healthy controls. In the preterm-born adults, MUC5AC expression correlated negatively with forced expiratory volume in 1 s to forced vital capacity ratio (FEV1/FVC) and positively with St George's Respiratory Questionnaire scores. Preterm-born adults with high MUC5AC expression had more bronchial hyperreactivity than those with low expression. MUC5B expression was lower in preterm-born adults with bronchial hyperreactivity and higher in those who reported having phlegm compared with those who did not have these signs.
CONCLUSIONS: Unlike patients with asthma, preterm-born adults with or without BPD do not exhibit increased MUC5AC expression compared with healthy controls. However, the associations of MUC5AC and MUC5B expression with lung function, symptoms and quality-of-life indices suggest a potential clinical role for these mucins in this population.