Guided Bone Regeneration (GBR) for Reconstructing Alveolar Bone Defects Following Resective Treatment of Medication-Related Osteonecrosis of the Jaws (MRONJ) Lesions: A Case Series.

This case series describes three patients with medication-related osteonecrosis of the jaw (MRONJ) treated by surgical resection combined with guided bone regeneration (GBR). All patients had a history of prolonged antiresorptive therapy and developed stage 3 MRONJ following dentoalveolar procedures. Treatment consisted of marginal resection or sequestrectomy followed by GBR using combinations of different bone substitutes, membranes, and recombinant human bone morphogenetic protein-2 (rhBMP-2). Favorable healing was observed in all cases, with progressive bone regeneration confirmed radiographically and restoration of oral function achieved in two patients through successful implant rehabilitation. These findings suggest that MRONJ resection combined with GBR offers an effective, less invasive alternative to extensive reconstructive procedures in selected MRONJ patients, supporting both functional and esthetic rehabilitation while minimizing morbidity.