[Antihypertensive effect of enalapril and lisinopril administered in combination with nonsteroid anti-inflammatory agents].

AIM: To study the effects of nonsteroid antiinflammatory drugs (NSAID) on antihypertensive activity of ACE inhibitors with different metabolic activity.

MATERIAL AND

METHODS

30 patients aged 45-70 years with arterial hypertension of degree I-II who had moderate and high risk of cardiovascular complications and concomitant spinal osteochondrosis with radicular syndrome. 20 patients received sequential treatment. Four variants of the course treatment were used: 1) monotherapy with enalapril maleate (2 mg twice a day); 2) enalapril maleate (5 mg twice a day) in combination with NSAID; 3) monotherapy with lisinopril (10 mg once a day); 4) lisinopril (10 mg once a day in combination with NSAID. 10 patients received enalapril (10 mg once a day) and acetylsalicylic acid (500 and 100 mg).

RESULTS

To the end of the treatment week 2 good and satisfactory antihypertensive effect was achieved in 70 and 85% on enalapril and lisinopril, respectively. NSAID addition to enalapril worsened its antihypertensive activity, to lisinopril--the negative effect was much less.

CONCLUSION

The data suggest metabolic conception of competitive interaction of ACE inhibitors with NSAID. Therefore, ACE inhibitors should be used differentially in active therapy with NSAID.