Multiple sclerosis in pregnancy: a review.

This case history discussed multiple sclerosis that began during pregnancy, in a patient with a history of juvenile rheumatoid arthritis. The etiology, epidemiology, pathophysiology, diagnosis, clinical course, and management of MS are reviewed from the point of view of an obstetrician, with emphasis on the interaction between MS and pregnancy. The similarities and differences between MS and rheumatoid arthritis, with respect to the effect of pregnancy on these diseases, is discussed. Because of the generally beneficial effect of pregnancy on MS and rheumatoid arthritis, and the frequent exacerbations of both diseases seen in the postpartum period, further studies of the relationship between pregnancy and these diseases may provide clues to the immunology and treatment of multiple sclerosis and other autoimmune diseases.