Journal of neurology · 2025
Поправка: Фармакогеномика клинической реакции на Натализумаб при множественном склерозе: исследование многоцентральной ассоциации генома.
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Clarelli Ferdinando, Corona Andrea, Pääkkönen Kimmo, Sorosina Melissa, Zollo Alen, Piehl Fredrik, Olsson Tomas, Stridh Pernilla, Jagodic Maja, Hemmer Bernhard, Gasperi Christiane, Harroud Adil, Shchetynsky Klementy, Mingione Alessandra, Mascia Elisabetta, Misra Kaalindi, Giordano Antonino, Mazzieri Maria Laura Terzi, Priori Alberto, Saarela Janna, Kockum Ingrid, Filippi Massimo, Esposito Federica, Martinelli Boneschi Filippo
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Оригинал публикации
Correction: Pharmacogenomics of clinical response to Natalizumab in multiple sclerosis: a genome-wide multi-centric association study.
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Correction: Journal of Neurology (2024) 271:7250–7263 10.1007/s00415-024-12608-6
In the original version of this article, author’s name Filippo Martinelli Boneschi was incorrectly written as Filippo Giovanni Martinelli Boneschi.
In Table 2, first two columns were missing. The Table 2 which previously appeared as
Table 2 List of top-associated variants after meta-analysis. The list is obtained upon a clumping procedure (see Methods for details), filtered at p < 5 × 10 –5 . The effect allele is the minor allele Position Minor allele Major allele MAF P OR SE I 2 Gene Genomic context Distance to gene 187,410,850 T C 0.268 1.328E−06 0.582 0.112 0 F11-AS1 ncRNA_intronic 68,071,570 T C 0.421 1.678E−06 1.538 0.090 0 PIGH; ARG2 Intergenic Dist = 4552; Dist = 15,067 111,037,829 T A 0.251 2.793E−06 0.596 0.111 13 KLF4; ACTL7B Intergenic Dist = 785,779; Dist = 579,040 20,863,249 G A 0.057 4.804E−06 2.122 0.165 0 GJB6; CRYL1 Intergenic Dist = 56,715; Dist = 114,557 98,275,102 C G 0.429 6.938E−06 0.650 0.096 34 LOC101927310; LINC00923 Intergenic Dist = 171,174; Dist = 10,744 47,775,385 A G 0.230 1.187E−05 1.561 0.102 0 SEMA6D Intronic 21,728,917 A G 0.142 1.191E−05 0.510 0.154 0 ZNF385D Intronic 187,402,360 A G 0.480 1.233E−05 1.496 0.092 0 F11-AS1 ncRNA_intronic 115,392,100 A G 0.347 1.259E−05 1.476 0.089 0 GAP43 Intronic 12,783,519 T C 0.075 1.325E−05 1.934 0.151 0 LINC00681; TRMT9B Intergenic Dist = 107,719; Dist = 19,663 43,181,587 T C 0.080 1.362E−05 1.918 0.150 0 A4GALT; ARFGAP3 Intergenic Dist = 64,280; Dist = 10,922 79,303,163 G A 0.430 1.475E−05 1.469 0.089 0 WWOX; MAF Intergenic Dist = 56,599; Dist = 324,572 98,347,870 C G 0.429 1.494E−05 0.676 0.091 57 LINC00923 ncRNA_intronic 27,204,531 C T 0.095 2.087E−05 1.775 0.135 42 ABI1; FAM238C Intergenic Dist = 54,515; Dist = 15,604 47,746,678 C G 0.075 2.692E−05 1.839 0.145 29 STIL Exonic 113,293,608 G A 0.411 2.744E−05 1.461 0.090 0 TUBGCP3; ATP11AUN Intergenic Dist = 51,109; Dist = 7750 606,173 C A 0.143 2.862E−05 1.646 0.119 0 B4GALNT3 Intronic 83,766,280 A C 0.114 2.909E−05 1.739 0.132 48 DLG2 Intronic 236,647,736 T C 0.233 2.939E−05 1.495 0.096 0 EDARADD UTR3 NM_145861 :c.*1787C>T; NM_080738 :c.*1787C>T 93,450,212 A G 0.295 3.023E−05 1.471 0.093 0 RUNX1T1; LOC102724710 Intergenic Dist = 334,599; Dist = 127,459 4,314,917 A G 0.220 3.087E−05 1.523 0.101 0 CSMD1 Intronic 81,279,746 A G 0.271 3.116E−05 1.479 0.094 6.4 SPRY2; LINC00377 Intergenic Dist = 364,485; Dist = 312,780 111,023,899 T C 0.404 3.369E−05 1.441 0.088 0 KLF4; ACTL7B Intergenic Dist = 771,849; Dist = 592,970 189,243,943 T C 0.413 3.424E−05 1.433 0.087 0 TPRG1; TP63 Intergenic Dist = 200,850; Dist = 70,592 114,813,313 C T 0.267 3.459E−05 1.483 0.095 0 TBX5 Intronic 110,446,839 G A 0.413 3.508E−05 1.433 0.087 0 IRS2; LINC00396 Intergenic Dist = 7909; Dist = 258,793 177,987,660 G A 0.137 3.639E−05 1.617 0.116 0 CRYZL2P ncRNA_intronic 31,271,788 A G 0.072 3.733E−05 1.845 0.148 60 OVOS2 ncRNA_intronic 206,468,850 T G 0.419 4.007E−05 1.433 0.088 0 PARD3B Intronic 54,692,961 G A 0.116 4.025E−05 1.652 0.122 6.9 TINAG; FAM83B Intergenic Dist = 438,021; Dist = 18,608 141,938,633 C T 0.069 4.217E−05 1.890 0.155 74 MGAM2; MOXD2P Intergenic Dist = 16,509; Dist = 1923 81,959,114 T C 0.499 4.222E−05 0.697 0.088 5.8 ATP6AP1L; MIR3977 Intergenic Dist = 343,363; Dist = 176,860 158,058,545 T C 0.436 4.257E−05 1.455 0.092 0 ZDHHC14 Intronic 180,648,923 C T 0.480 4.571E−05 0.699 0.088 0 LINC01098; LINC00290 Intergenic Dist = 1,737,019; Dist = 1,336,320 83,182,354 A G 0.299 4.605E−05 1.458 0.093 0 DLG2 Intronic 10,732,844 G A 0.050 4.841E−05 2.053 0.177 53 TEKT5 Intronic 130,499,623 G A 0.096 4.929E−05 1.749 0.138 42 LINC01163; LINC02667 Intergenic Dist = 383,633; Dist = 211,474 156,675,608 A C 0.135 4.934E−05 1.642 0.122 0 GUCY1A1; GUCY1B1 Intergenic Dist = 17,399; Dist = 4565 50,679,081 T G 0.372 4.966E−05 1.448 0.091 0 DEFB112; TFAP2D Intergenic Dist = 661,439; Dist = 2158 For each variant, the gene harboring it or nearest gene(s) are reported, together with its genomic context and distance in base-pairs from the nearest genes, as of ANNOVAR annotation Abbreviations: MAF (Minor Allele Frequency), P (p value from fixed-effect meta-analysis), OR (odds ratio from fixed-effects meta-analysis), SE (standard error), I 2 (heterogeneity index)
List of top-associated variants after meta-analysis. The list is obtained upon a clumping procedure (see Methods for details), filtered at p < 5 × 10 –5 . The effect allele is the minor allele
For each variant, the gene harboring it or nearest gene(s) are reported, together with its genomic context and distance in base-pairs from the nearest genes, as of ANNOVAR annotation
Abbreviations: MAF (Minor Allele Frequency), P (p value from fixed-effect meta-analysis), OR (odds ratio from fixed-effects meta-analysis), SE (standard error), I 2 (heterogeneity index)
but Table 2 should have appeared as shown below.
Table 2 List of top associated variants after meta-analysis SNP Chromosome Position Minor allele Major allele MAF P OR SE I 2 Gene Genomic context Distance to gene rs11132400 4 187410850 T C 0.268 1.328E−06 0.582 0.112 0 F11-AS1 ncRNA_intronic rs12885261 14 68071570 T C 0.421 1.678E−06 1.538 0.090 0 PIGH; ARG2 Intergenic dist = 4552; dist = 15,067 rs1323374 9 111037829 T A 0.251 2.793E−06 0.596 0.111 13 KLF4; ACTL7B Intergenic dist = 785,779; dist = 579,040 rs61166479 13 20863249 G A 0.057 4.804E−06 2.122 0.165 0 GJB6; CRYL1 Intergenic dist = 56,715; dist = 114,557 rs1032954 15 98275102 C G 0.429 6.938E−06 0.650 0.096 34 LOC101927310; LINC00923 Intergenic dist = 171,174; dist = 10,744 rs75772884 15 47775385 A G 0.230 1.187E−05 1.561 0.102 0 SEMA6D Intronic rs34736466 3 21728917 A G 0.142 1.191E−05 0.510 0.154 0 ZNF385D Intronic rs12649886 4 187402360 A G 0.480 1.233E−05 1.496 0.092 0 F11-AS1 ncRNA_intronic rs13073759 3 115392100 A G 0.347 1.259E−05 1.476 0.089 0 GAP43 Intronic rs2977141 8 12783519 T C 0.075 1.325E−05 1.934 0.151 0 LINC00681; TRMT9B Intergenic dist = 107,719; dist = 19,663 rs7286822 22 43181587 T C 0.080 1.362E−05 1.918 0.150 0 A4GALT; ARFGAP3 Intergenic dist = 64,280; dist = 10,922 rs9922330 16 79303163 G A 0.430 1.475E−05 1.469 0.089 0 WWOX; MAF Intergenic dist = 56,599; dist = 324,572 rs72752604 15 98347870 C G 0.429 1.494E−05 0.676 0.091 57 LINC00923 ncRNA_intronic rs1815323 10 27204531 C T 0.095 2.087E−05 1.775 0.135 42 ABI1; FAM238C Intergenic dist = 54,515; dist = 15,604 rs10789505 1 47746678 C G 0.075 2.692E−05 1.839 0.145 29 STIL Exonic rs9577824 13 113293608 G A 0.411 2.744E−05 1.461 0.090 0 TUBGCP3; ATP11AUN Intergenic dist = 51,109; dist = 7750 rs2159600 12 606173 C A 0.143 2.862E−05 1.646 0.119 0 B4GALNT3 Intronic rs12806160 11 83766280 A C 0.114 2.909E−05 1.739 0.132 48 DLG2 Intronic rs6428955 1 236647736 T C 0.233 2.939E−05 1.495 0.096 0 EDARADD UTR3 NM_145861 :c.*1787C > T; NM_080738 :c.*1787C > T rs1072934 8 93450212 A G 0.295 3.023E−05 1.471 0.093 0 RUNX1T1; LOC102724710 Intergenic dist = 334,599; dist = 127,459 rs1217680 8 4314917 A G 0.220 3.087E−05 1.523 0.101 0 CSMD1 Intronic rs12428095 13 81279746 A G 0.271 3.116E−05 1.479 0.094 6.4 SPRY2; LINC00377 Intergenic dist = 364,485; dist = 312,780 rs10739255 9 111023899 T C 0.404 3.369E−05 1.441 0.088 0 KLF4; ACTL7B Intergenic dist = 771,849; dist = 592,970 rs6803844 3 189243943 T C 0.413 3.424E−05 1.433 0.087 0 TPRG1; TP63 Intergenic dist = 200,850; dist = 70,592 rs7960396 12 114813313 C T 0.267 3.459E−05 1.483 0.095 0 TBX5 Intronic rs1414319 13 110446839 G A 0.413 3.508E−05 1.433 0.087 0 IRS2; LINC00396 Intergenic dist = 7909; dist = 258,793 rs7537568 1 177987660 G A 0.137 3.639E−05 1.617 0.116 0 CRYZL2P ncRNA_intronic rs112417083 12 31271788 A G 0.072 3.733E−05 1.845 0.148 60 OVOS2 ncRNA_intronic rs13031793 2 206468850 T G 0.419 4.007E−05 1.433 0.088 0 PARD3B Intronic rs9475026 6 54692961 G A 0.116 4.025E−05 1.652 0.122 6.9 TINAG; FAM83B Intergenic dist = 438,021; dist = 18,608 rs59801030 7 141938633 C T 0.069 4.217E−05 1.890 0.155 74 MGAM2; MOXD2P Intergenic dist = 16,509; dist = 1923 rs10040233 5 81959114 T C 0.499 4.222E−05 0.697 0.088 5.8 ATP6AP1L; MIR3977 Intergenic dist = 343,363; dist = 176,860 rs618823 6 158058545 T C 0.436 4.257E−05 1.455 0.092 0 ZDHHC14 Intronic rs4444875 4 180648923 C T 0.480 4.571E−05 0.699 0.088 0 LINC01098; LINC00290 Intergenic dist = 1,737,019; dist = 1,336,320 rs2068076 11 83182354 A G 0.299 4.605E−05 1.458 0.093 0 DLG2 Intronic rs76674464 16 10732844 G A 0.050 4.841E−05 2.053 0.177 53 TEKT5 Intronic rs12265034 10 130499623 G A 0.096 4.929E−05 1.749 0.138 42 LINC01163; LINC02667 Intergenic dist = 383,633; dist = 211,474 rs6838876 4 156675608 A C 0.135 4.934E−05 1.642 0.122 0 GUCY1A1; GUCY1B1 Intergenic dist = 17,399; dist = 4565 rs1923523 6 50679081 T G 0.372 4.966E−05 1.448 0.091 0 DEFB112; TFAP2D Intergenic dist = 661,439; dist = 2158 The list is obtained upon a clumping procedure (see Methods for details), filtered at p < 5 × 10 −5 . The effect allele is the minor allele For each variant, the gene harboring it or nearest gene(s) are reported, together with its genomic context and distance in base-pairs from the nearest genes, as of ANNOVAR annotation MAF (Minor Allele Frequency), P (p-value from fixed-effect meta-analysis), OR (odds ratio from fixed-effects meta-analysis), SE (standard error), I 2 (heterogeneity index)
List of top associated variants after meta-analysis
The list is obtained upon a clumping procedure (see Methods for details), filtered at p < 5 × 10 −5 . The effect allele is the minor allele
For each variant, the gene harboring it or nearest gene(s) are reported, together with its genomic context and distance in base-pairs from the nearest genes, as of ANNOVAR annotation
MAF (Minor Allele Frequency), P (p-value from fixed-effect meta-analysis), OR (odds ratio from fixed-effects meta-analysis), SE (standard error), I 2 (heterogeneity index)
Contributor Information
Federica Esposito, Email: esposito.federica@hsr.it.
Filippo Martinelli Boneschi, Email: filippo.martinelli@unimi.it.
In the original version of this article, author’s name Filippo Martinelli Boneschi was incorrectly written as Filippo Giovanni Martinelli Boneschi.
In Table 2, first two columns were missing. The Table 2 which previously appeared as
Table 2 List of top-associated variants after meta-analysis. The list is obtained upon a clumping procedure (see Methods for details), filtered at p < 5 × 10 –5 . The effect allele is the minor allele Position Minor allele Major allele MAF P OR SE I 2 Gene Genomic context Distance to gene 187,410,850 T C 0.268 1.328E−06 0.582 0.112 0 F11-AS1 ncRNA_intronic 68,071,570 T C 0.421 1.678E−06 1.538 0.090 0 PIGH; ARG2 Intergenic Dist = 4552; Dist = 15,067 111,037,829 T A 0.251 2.793E−06 0.596 0.111 13 KLF4; ACTL7B Intergenic Dist = 785,779; Dist = 579,040 20,863,249 G A 0.057 4.804E−06 2.122 0.165 0 GJB6; CRYL1 Intergenic Dist = 56,715; Dist = 114,557 98,275,102 C G 0.429 6.938E−06 0.650 0.096 34 LOC101927310; LINC00923 Intergenic Dist = 171,174; Dist = 10,744 47,775,385 A G 0.230 1.187E−05 1.561 0.102 0 SEMA6D Intronic 21,728,917 A G 0.142 1.191E−05 0.510 0.154 0 ZNF385D Intronic 187,402,360 A G 0.480 1.233E−05 1.496 0.092 0 F11-AS1 ncRNA_intronic 115,392,100 A G 0.347 1.259E−05 1.476 0.089 0 GAP43 Intronic 12,783,519 T C 0.075 1.325E−05 1.934 0.151 0 LINC00681; TRMT9B Intergenic Dist = 107,719; Dist = 19,663 43,181,587 T C 0.080 1.362E−05 1.918 0.150 0 A4GALT; ARFGAP3 Intergenic Dist = 64,280; Dist = 10,922 79,303,163 G A 0.430 1.475E−05 1.469 0.089 0 WWOX; MAF Intergenic Dist = 56,599; Dist = 324,572 98,347,870 C G 0.429 1.494E−05 0.676 0.091 57 LINC00923 ncRNA_intronic 27,204,531 C T 0.095 2.087E−05 1.775 0.135 42 ABI1; FAM238C Intergenic Dist = 54,515; Dist = 15,604 47,746,678 C G 0.075 2.692E−05 1.839 0.145 29 STIL Exonic 113,293,608 G A 0.411 2.744E−05 1.461 0.090 0 TUBGCP3; ATP11AUN Intergenic Dist = 51,109; Dist = 7750 606,173 C A 0.143 2.862E−05 1.646 0.119 0 B4GALNT3 Intronic 83,766,280 A C 0.114 2.909E−05 1.739 0.132 48 DLG2 Intronic 236,647,736 T C 0.233 2.939E−05 1.495 0.096 0 EDARADD UTR3 NM_145861 :c.*1787C>T; NM_080738 :c.*1787C>T 93,450,212 A G 0.295 3.023E−05 1.471 0.093 0 RUNX1T1; LOC102724710 Intergenic Dist = 334,599; Dist = 127,459 4,314,917 A G 0.220 3.087E−05 1.523 0.101 0 CSMD1 Intronic 81,279,746 A G 0.271 3.116E−05 1.479 0.094 6.4 SPRY2; LINC00377 Intergenic Dist = 364,485; Dist = 312,780 111,023,899 T C 0.404 3.369E−05 1.441 0.088 0 KLF4; ACTL7B Intergenic Dist = 771,849; Dist = 592,970 189,243,943 T C 0.413 3.424E−05 1.433 0.087 0 TPRG1; TP63 Intergenic Dist = 200,850; Dist = 70,592 114,813,313 C T 0.267 3.459E−05 1.483 0.095 0 TBX5 Intronic 110,446,839 G A 0.413 3.508E−05 1.433 0.087 0 IRS2; LINC00396 Intergenic Dist = 7909; Dist = 258,793 177,987,660 G A 0.137 3.639E−05 1.617 0.116 0 CRYZL2P ncRNA_intronic 31,271,788 A G 0.072 3.733E−05 1.845 0.148 60 OVOS2 ncRNA_intronic 206,468,850 T G 0.419 4.007E−05 1.433 0.088 0 PARD3B Intronic 54,692,961 G A 0.116 4.025E−05 1.652 0.122 6.9 TINAG; FAM83B Intergenic Dist = 438,021; Dist = 18,608 141,938,633 C T 0.069 4.217E−05 1.890 0.155 74 MGAM2; MOXD2P Intergenic Dist = 16,509; Dist = 1923 81,959,114 T C 0.499 4.222E−05 0.697 0.088 5.8 ATP6AP1L; MIR3977 Intergenic Dist = 343,363; Dist = 176,860 158,058,545 T C 0.436 4.257E−05 1.455 0.092 0 ZDHHC14 Intronic 180,648,923 C T 0.480 4.571E−05 0.699 0.088 0 LINC01098; LINC00290 Intergenic Dist = 1,737,019; Dist = 1,336,320 83,182,354 A G 0.299 4.605E−05 1.458 0.093 0 DLG2 Intronic 10,732,844 G A 0.050 4.841E−05 2.053 0.177 53 TEKT5 Intronic 130,499,623 G A 0.096 4.929E−05 1.749 0.138 42 LINC01163; LINC02667 Intergenic Dist = 383,633; Dist = 211,474 156,675,608 A C 0.135 4.934E−05 1.642 0.122 0 GUCY1A1; GUCY1B1 Intergenic Dist = 17,399; Dist = 4565 50,679,081 T G 0.372 4.966E−05 1.448 0.091 0 DEFB112; TFAP2D Intergenic Dist = 661,439; Dist = 2158 For each variant, the gene harboring it or nearest gene(s) are reported, together with its genomic context and distance in base-pairs from the nearest genes, as of ANNOVAR annotation Abbreviations: MAF (Minor Allele Frequency), P (p value from fixed-effect meta-analysis), OR (odds ratio from fixed-effects meta-analysis), SE (standard error), I 2 (heterogeneity index)
List of top-associated variants after meta-analysis. The list is obtained upon a clumping procedure (see Methods for details), filtered at p < 5 × 10 –5 . The effect allele is the minor allele
For each variant, the gene harboring it or nearest gene(s) are reported, together with its genomic context and distance in base-pairs from the nearest genes, as of ANNOVAR annotation
Abbreviations: MAF (Minor Allele Frequency), P (p value from fixed-effect meta-analysis), OR (odds ratio from fixed-effects meta-analysis), SE (standard error), I 2 (heterogeneity index)
but Table 2 should have appeared as shown below.
Table 2 List of top associated variants after meta-analysis SNP Chromosome Position Minor allele Major allele MAF P OR SE I 2 Gene Genomic context Distance to gene rs11132400 4 187410850 T C 0.268 1.328E−06 0.582 0.112 0 F11-AS1 ncRNA_intronic rs12885261 14 68071570 T C 0.421 1.678E−06 1.538 0.090 0 PIGH; ARG2 Intergenic dist = 4552; dist = 15,067 rs1323374 9 111037829 T A 0.251 2.793E−06 0.596 0.111 13 KLF4; ACTL7B Intergenic dist = 785,779; dist = 579,040 rs61166479 13 20863249 G A 0.057 4.804E−06 2.122 0.165 0 GJB6; CRYL1 Intergenic dist = 56,715; dist = 114,557 rs1032954 15 98275102 C G 0.429 6.938E−06 0.650 0.096 34 LOC101927310; LINC00923 Intergenic dist = 171,174; dist = 10,744 rs75772884 15 47775385 A G 0.230 1.187E−05 1.561 0.102 0 SEMA6D Intronic rs34736466 3 21728917 A G 0.142 1.191E−05 0.510 0.154 0 ZNF385D Intronic rs12649886 4 187402360 A G 0.480 1.233E−05 1.496 0.092 0 F11-AS1 ncRNA_intronic rs13073759 3 115392100 A G 0.347 1.259E−05 1.476 0.089 0 GAP43 Intronic rs2977141 8 12783519 T C 0.075 1.325E−05 1.934 0.151 0 LINC00681; TRMT9B Intergenic dist = 107,719; dist = 19,663 rs7286822 22 43181587 T C 0.080 1.362E−05 1.918 0.150 0 A4GALT; ARFGAP3 Intergenic dist = 64,280; dist = 10,922 rs9922330 16 79303163 G A 0.430 1.475E−05 1.469 0.089 0 WWOX; MAF Intergenic dist = 56,599; dist = 324,572 rs72752604 15 98347870 C G 0.429 1.494E−05 0.676 0.091 57 LINC00923 ncRNA_intronic rs1815323 10 27204531 C T 0.095 2.087E−05 1.775 0.135 42 ABI1; FAM238C Intergenic dist = 54,515; dist = 15,604 rs10789505 1 47746678 C G 0.075 2.692E−05 1.839 0.145 29 STIL Exonic rs9577824 13 113293608 G A 0.411 2.744E−05 1.461 0.090 0 TUBGCP3; ATP11AUN Intergenic dist = 51,109; dist = 7750 rs2159600 12 606173 C A 0.143 2.862E−05 1.646 0.119 0 B4GALNT3 Intronic rs12806160 11 83766280 A C 0.114 2.909E−05 1.739 0.132 48 DLG2 Intronic rs6428955 1 236647736 T C 0.233 2.939E−05 1.495 0.096 0 EDARADD UTR3 NM_145861 :c.*1787C > T; NM_080738 :c.*1787C > T rs1072934 8 93450212 A G 0.295 3.023E−05 1.471 0.093 0 RUNX1T1; LOC102724710 Intergenic dist = 334,599; dist = 127,459 rs1217680 8 4314917 A G 0.220 3.087E−05 1.523 0.101 0 CSMD1 Intronic rs12428095 13 81279746 A G 0.271 3.116E−05 1.479 0.094 6.4 SPRY2; LINC00377 Intergenic dist = 364,485; dist = 312,780 rs10739255 9 111023899 T C 0.404 3.369E−05 1.441 0.088 0 KLF4; ACTL7B Intergenic dist = 771,849; dist = 592,970 rs6803844 3 189243943 T C 0.413 3.424E−05 1.433 0.087 0 TPRG1; TP63 Intergenic dist = 200,850; dist = 70,592 rs7960396 12 114813313 C T 0.267 3.459E−05 1.483 0.095 0 TBX5 Intronic rs1414319 13 110446839 G A 0.413 3.508E−05 1.433 0.087 0 IRS2; LINC00396 Intergenic dist = 7909; dist = 258,793 rs7537568 1 177987660 G A 0.137 3.639E−05 1.617 0.116 0 CRYZL2P ncRNA_intronic rs112417083 12 31271788 A G 0.072 3.733E−05 1.845 0.148 60 OVOS2 ncRNA_intronic rs13031793 2 206468850 T G 0.419 4.007E−05 1.433 0.088 0 PARD3B Intronic rs9475026 6 54692961 G A 0.116 4.025E−05 1.652 0.122 6.9 TINAG; FAM83B Intergenic dist = 438,021; dist = 18,608 rs59801030 7 141938633 C T 0.069 4.217E−05 1.890 0.155 74 MGAM2; MOXD2P Intergenic dist = 16,509; dist = 1923 rs10040233 5 81959114 T C 0.499 4.222E−05 0.697 0.088 5.8 ATP6AP1L; MIR3977 Intergenic dist = 343,363; dist = 176,860 rs618823 6 158058545 T C 0.436 4.257E−05 1.455 0.092 0 ZDHHC14 Intronic rs4444875 4 180648923 C T 0.480 4.571E−05 0.699 0.088 0 LINC01098; LINC00290 Intergenic dist = 1,737,019; dist = 1,336,320 rs2068076 11 83182354 A G 0.299 4.605E−05 1.458 0.093 0 DLG2 Intronic rs76674464 16 10732844 G A 0.050 4.841E−05 2.053 0.177 53 TEKT5 Intronic rs12265034 10 130499623 G A 0.096 4.929E−05 1.749 0.138 42 LINC01163; LINC02667 Intergenic dist = 383,633; dist = 211,474 rs6838876 4 156675608 A C 0.135 4.934E−05 1.642 0.122 0 GUCY1A1; GUCY1B1 Intergenic dist = 17,399; dist = 4565 rs1923523 6 50679081 T G 0.372 4.966E−05 1.448 0.091 0 DEFB112; TFAP2D Intergenic dist = 661,439; dist = 2158 The list is obtained upon a clumping procedure (see Methods for details), filtered at p < 5 × 10 −5 . The effect allele is the minor allele For each variant, the gene harboring it or nearest gene(s) are reported, together with its genomic context and distance in base-pairs from the nearest genes, as of ANNOVAR annotation MAF (Minor Allele Frequency), P (p-value from fixed-effect meta-analysis), OR (odds ratio from fixed-effects meta-analysis), SE (standard error), I 2 (heterogeneity index)
List of top associated variants after meta-analysis
The list is obtained upon a clumping procedure (see Methods for details), filtered at p < 5 × 10 −5 . The effect allele is the minor allele
For each variant, the gene harboring it or nearest gene(s) are reported, together with its genomic context and distance in base-pairs from the nearest genes, as of ANNOVAR annotation
MAF (Minor Allele Frequency), P (p-value from fixed-effect meta-analysis), OR (odds ratio from fixed-effects meta-analysis), SE (standard error), I 2 (heterogeneity index)
Contributor Information
Federica Esposito, Email: esposito.federica@hsr.it.
Filippo Martinelli Boneschi, Email: filippo.martinelli@unimi.it.