Nature microbiology · 2026
Early-life colonization by aromatic-lactate-producing bifidobacteria lowers the risk of allergic sensitization.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Myers Pernille Neve, Dehli Rasmus Kaae, Mie Axel, Moll Janne Marie, Roager Henrik Munch, Eriksen Carsten, Laursen Martin Frederik, Staudinger Ellen Magdalena, Chatzigiannidou Ioanna, Johansen Pi Lærke, van Best Niels, O'Hely Martin, Andersen Daniel, Nørregaard Nadja Lund, Pedersen Mikael, Hamelmann Eckard, Lau Susanne, Bahl Martin Iain, Abou Hachem Maher, Licht Tine Rask, Nielsen Henrik Bjørn, Thysen Anna Hammerich, Vuillermin Peter, Penders John, Kristiansen Karsten, Scheynius Annika, Alm Johan, Brix Susanne
Аннотация
Early-life microbial exposures shape immune development and allergy risk. Food allergen sensitization, reflected by the presence of food allergen-specific immunoglobulin E (IgE), is an early indication of impaired immune tolerance. Here we show that early-life transmission of aromatic lactate-producing bifidobacteria strains in 147 children followed from birth to 5 years of age, facilitated by vaginal delivery, exposure to older siblings and exclusive breastfeeding for the first 2 months, led to increased levels of aromatic lactates in the infant gut. This microbiota-metabolite signature was inversely associated with the development of food allergen-specific IgE until 5 years and atopic dermatitis at 2 years. The observed effect was mediated by 4-hydroxy-phenyllactate, which inhibited IgE, but not IgG, production in ex vivo human immune cell cultures. Together, these findings define an early-life microbiota-metabolite-immune axis linking microbial transmission and feeding practices with reduced allergic sensitization.