Stem cell research & therapy · 2026
Exosome-derived LncRNAs in bone remodeling: recent advances and future directions for bone disease therapy.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Zhang Shihua, Wang Hui, Zhao Chenyu, Zhu Chenyu, Li Xun, Su Zhi'ang, Zou Jun, Wang Chong, Zhang Lan, Yuan Yu, Tian Xuewen
Аннотация
BACKGROUND: Exosomes derived from various cellular sources play a pivotal role in mediating and regulating bone and cartilage regeneration for conditions such as bone defects, fractures, cartilage repair, osteoporosis, and osteoarthritis.
MAINTEXT: As essential intercellular communication vehicles, exosomes transmit long non-coding RNAs (lncRNAs) to modulate cellular behaviors in the bone microenvironment, which has been a central focus of contemporary research.This review consolidates existing evidence on exosome-derived lncRNAs in bone remodeling, revealing their regulatory roles through signaling pathway networks on osteoclasts, osteoblasts, and related bone/cartilage lineage cells, including mesenchymal stem cells, chondrocytes, and osteoclasts. Exosome-encapsulated lncRNAs that regulate osteogenic differentiation of bone marrow mesenchymal stem cells, osteoclast activity, bone-vascular coupling, and bone metastasis show promise as minimally invasive biomarkers for diagnosis, risk stratification, and therapeutic monitoring of bone metabolic disorders.
CONCLUSION: Moreover, harnessing exosomes as natural, engineerable delivery vehicles can advance the development of bone-targeted, precise, and low-toxicity therapeutic strategies to complement existing pharmacologic and regenerative treatments.
MAINTEXT: As essential intercellular communication vehicles, exosomes transmit long non-coding RNAs (lncRNAs) to modulate cellular behaviors in the bone microenvironment, which has been a central focus of contemporary research.This review consolidates existing evidence on exosome-derived lncRNAs in bone remodeling, revealing their regulatory roles through signaling pathway networks on osteoclasts, osteoblasts, and related bone/cartilage lineage cells, including mesenchymal stem cells, chondrocytes, and osteoclasts. Exosome-encapsulated lncRNAs that regulate osteogenic differentiation of bone marrow mesenchymal stem cells, osteoclast activity, bone-vascular coupling, and bone metastasis show promise as minimally invasive biomarkers for diagnosis, risk stratification, and therapeutic monitoring of bone metabolic disorders.
CONCLUSION: Moreover, harnessing exosomes as natural, engineerable delivery vehicles can advance the development of bone-targeted, precise, and low-toxicity therapeutic strategies to complement existing pharmacologic and regenerative treatments.