Molecular Biomarkers and Clinical Predictors of Psoriatic Arthritis.

Psoriatic arthritis (PsA) is an inflammatory musculoskeletal disorder affecting approximately 30% of patients with psoriasis (PsO). Despite the high prevalence of PsA among patients with psoriasis, there is no single validated laboratory, imaging, or clinical test that can diagnose PsA. There is growing interest in using molecular biomarkers for prediction and early diagnosis of PsA. These molecular biomarkers will be discussed in this review and include blood-based proteins, genetic polymorphisms, synovial tissue biomarkers, and skin and microbiome alterations.