Nutrients · 2026
Phenylethanoid Glycosides from Cistanche deserticola Y. C. Ma: Synergistic Effects, Multi-target Mechanisms and Translational Applications.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Liu Xiaofeng, Han Minjun, Yang Zichao, Chen Zherui, Zhang Yao, Guan Rongfa
Аннотация
BACKGROUND: Cistanche deserticola Y. C. Ma (C. deserticola) is a widely recognized medicinal and edible homologous plant. Phenylethanoid glycosides (PhGs), as its dominant bioactive components, are characterized by diverse chemical structures and prominent multi-target synergistic pharmacological activities. This review aims to systematically outline the structural characteristics, structure-activity relationships, and pharmacological mechanisms of typical PhGs from C. deserticola, so as to provide a scientific basis for their further development and application.
METHODS: A comprehensive literature review was performed. The structural features, structure-activity relationships, and multi-dimensional pharmacological mechanisms of representative PhGs, including echinacoside, verbascoside, and cistanoside A, were systematically summarized and analyzed.
RESULTS: PhGs exert anti-inflammatory, antioxidant, immunomodulatory, neuroprotective, antitumor, and hepatoprotective effects mainly by regulating multiple signaling pathways, such as NF-κB, MAPK, PI3K/Akt, and Nrf2/HO-1. These compounds display promising application potential in the prevention and amelioration of chronic inflammatory diseases, aging-related disorders including Alzheimer's disease and osteoporosis, as well as oxidative stress-induced injury.
CONCLUSIONS: PhGs from C. deserticola possess distinct pharmacological effects and broad application prospects. Future research should emphasize in-depth structure-activity relationship investigations, multi-component synergistic mechanisms, safety evaluation, and formulation design to enhance bioavailability, thus promoting the industrial development and application of PhGs.
METHODS: A comprehensive literature review was performed. The structural features, structure-activity relationships, and multi-dimensional pharmacological mechanisms of representative PhGs, including echinacoside, verbascoside, and cistanoside A, were systematically summarized and analyzed.
RESULTS: PhGs exert anti-inflammatory, antioxidant, immunomodulatory, neuroprotective, antitumor, and hepatoprotective effects mainly by regulating multiple signaling pathways, such as NF-κB, MAPK, PI3K/Akt, and Nrf2/HO-1. These compounds display promising application potential in the prevention and amelioration of chronic inflammatory diseases, aging-related disorders including Alzheimer's disease and osteoporosis, as well as oxidative stress-induced injury.
CONCLUSIONS: PhGs from C. deserticola possess distinct pharmacological effects and broad application prospects. Future research should emphasize in-depth structure-activity relationship investigations, multi-component synergistic mechanisms, safety evaluation, and formulation design to enhance bioavailability, thus promoting the industrial development and application of PhGs.