The Journal of clinical endocrinology and metabolism · 2016
68Ga-DOTATATE for Tumor Localization in Tumor-Induced Osteomalacia.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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El-Maouche Diala, Sadowski Samira M, Papadakis Georgios Z, Guthrie Lori, Cottle-Delisle Candice, Merkel Roxanne, Millo Corina, Chen Clara C, Kebebew Electron, Collins Michael T
Аннотация
CONTEXT: Phosphaturic mesenchymal tumors (PMTs) are small, typically difficult to localize, and express somatostatin receptors. Recent work suggests imaging studies using 68Gallium (68Ga)-conjugated somatostatin peptide analogues, such as 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)TATE, which enables somatostatin receptor imaging with positron emission tomography (PET), may be useful at identifying these tumors.
OBJECTIVE: Our objective was to evaluate the use of 68Ga-DOTATATE PET/computed tomography (CT) for tumor localization in tumor-induced osteomalacia (TIO).
DESIGN: This was a single-center prospective study of patients with TIO.
SETTING: The study was conducted at the National Institutes of Health Clinical Center between February 2014 and February 2015.
SUBJECTS: Eleven subjects (six females, five males) with TIO were included.
INTERVENTION: Subjects underwent 68Ga-DOTATATE PET/CT in addition to 111In-pentetreotide single-photon emission CT (Octreoscan- SPECT/CT) and fluorodeoxyglucose-PET/CT (18F FDG-PET/CT) scan.
MAIN OUTCOME MEASURES: Localization of PMTs on the previously described imaging modalities were determined.
RESULTS: The tumor was successfully localized in 6/11 (54.5%) subjects (one was metastatic). The tumor was identified by 68Ga-DOTATATE in all six cases. Both Octreoscan-SPECT/CT and 18F FDG-PET each identified the tumor in 4/6. In no cases was 68Ga-DOTATATE the only imaging study to identify the tumor.
CONCLUSIONS: In this first prospective study comparing 68Ga-DOTATATE PET/CT to Octreoscan-SPECT/CT and 18F FDG-PET in TIO localization, 68Ga-DOTATATE PET/CT demonstrated the greatest sensitivity and specificity, suggesting that it may be the best single study for localization of PMTs in TIO.
OBJECTIVE: Our objective was to evaluate the use of 68Ga-DOTATATE PET/computed tomography (CT) for tumor localization in tumor-induced osteomalacia (TIO).
DESIGN: This was a single-center prospective study of patients with TIO.
SETTING: The study was conducted at the National Institutes of Health Clinical Center between February 2014 and February 2015.
SUBJECTS: Eleven subjects (six females, five males) with TIO were included.
INTERVENTION: Subjects underwent 68Ga-DOTATATE PET/CT in addition to 111In-pentetreotide single-photon emission CT (Octreoscan- SPECT/CT) and fluorodeoxyglucose-PET/CT (18F FDG-PET/CT) scan.
MAIN OUTCOME MEASURES: Localization of PMTs on the previously described imaging modalities were determined.
RESULTS: The tumor was successfully localized in 6/11 (54.5%) subjects (one was metastatic). The tumor was identified by 68Ga-DOTATATE in all six cases. Both Octreoscan-SPECT/CT and 18F FDG-PET each identified the tumor in 4/6. In no cases was 68Ga-DOTATATE the only imaging study to identify the tumor.
CONCLUSIONS: In this first prospective study comparing 68Ga-DOTATATE PET/CT to Octreoscan-SPECT/CT and 18F FDG-PET in TIO localization, 68Ga-DOTATATE PET/CT demonstrated the greatest sensitivity and specificity, suggesting that it may be the best single study for localization of PMTs in TIO.
Предметные рубрики MeSH
AdolescentAdultCyclamsFemaleFluorodeoxyglucose F18Gallium RadioisotopesHeterocyclic CompoundsHumansMaleMiddle AgedMultimodal ImagingNeoplasm MetastasisNeoplasmsNeoplasms, Connective TissueOsteomalaciaParaneoplastic SyndromesPositron Emission Tomography Computed TomographyProspective StudiesRadiopharmaceuticalsReceptors, SomatostatinSomatostatinTomography, Emission-Computed, Single-PhotonYoung Adult