The role of ABHD2 in cigarette smoke-induced skeletal muscle atrophy in chronic obstructive pulmonary disease mice: The mechanism of ABHD2 in skeletal muscle atrophy.

Background

Chronic obstructive pulmonary disease (COPD) is a major and increasing global health problem that results in progressive airway obstruction. Cigarette smoke (CS) exposure, a major cause for COPD, induces mitochondrial damage, which has been implicated in sarcopenia pathogenesis. The current study sought to examine the involvement of ABHD2 in the mechanisms of development of COPD-related sarcopenia.

Methods

The involvement of ABHD2 was examined using in vivo CS-exposure model using ABHD2-KO mice. In CSE-induced COPD mouse models, ROS production and inflammation were measured using fluorescent probes and Western blot analysis.

Results

Increased ROS was responsible for myotube atrophy by activating Muscle Ring Finger 1 and inhibiting Myod. ABHD2-KO mice with prolonged CS exposure showed enhanced muscle atrophy.

Conclusion

These results indicated that ABHD2 played a key protective role in COPD-related skeletal muscle atrophy through a three-dimensional interactive network coordinating angiogenesis, oxidative stress defense, and inflammatory microenvironment regulation.