Natural product research · 2019
A new cytotoxic plumbagin derivative from roots of Diospyros undulata.
СтатьяНазвание и аннотация: Перевод в очереди
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Suchaichit Nattawut, Suchaichit Natcha P, Kanokmedhakul Kwanjai, Boottanun Patcharaporn, Sermswan Rasana W, Moosophon Panawan, Kanokmedhakul Somdej
Аннотация
A new plumbagin derivative, 3-(5-oxohexyl)plumbagin (1), together with six known benzoquinone derivatives (2-7), four known triterpenoids (8-11) and coniferyl aldehyde (12) were isolated from Diospyros undulata roots. Their structures were elucidated by intensive spectroscopy including 1 D and 2 D NMR, UV, IR and MS spectrometric analysis. Compound 1 exhibited strong cytotoxicity against three cancer cell lines as lung cancer (NCI-H187), breast cancer (MCF-7), and oral cancer (KB) with IC50 values of 7.16, 12.85 and 28.67 µM, respectively. Moreover, it did not showed cytotoxicity to Vero cells. In addition, the antimicrobial activity of compound 1 was moderate that kill only S. aureus with MBC of 250 µg/mL while other compounds especially compound 4 showed a broader activity that kill all tested bacteria.