Naunyn-Schmiedeberg's archives of pharmacology · 2024
Unraveling the impact of miRNAs on gouty arthritis: diagnostic significance and therapeutic opportunities.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Abdel Mageed Sherif S, Elimam Hanan, Elesawy Ahmed E, Abulsoud Ahmed I, Raouf Ahmed Amr, Tabaa Manar Mohammed El, Mohammed Osama A, Zaki Mohamed Bakr, Abd-Elmawla Mai A, El-Dakroury Walaa A, Mangoura Safwat Abdelhady, Elrebehy Mahmoud A, Elballal Mohammed S, Mohamed Aya A, Ashraf Alaa, Abdel-Reheim Mustafa Ahmed, Eleragi Ali M S, Abdellatif Hussein, Doghish Ahmed S
Аннотация
Gouty arthritis is a prevalent inflammatory illness. Gout attacks begin when there is an imbalance in the body's uric acid metabolism, which leads to urate buildup and the development of the ailment. A family of conserved, short non-coding RNAs known as microRNAs (miRNAs) can regulate post-transcriptional protein synthesis by attaching to the 3' untranslated region (UTR) of messenger RNA (mRNA). An increasing amount of research is pointing to miRNAs as potential players in several inflammatory diseases, including gouty arthritis. miRNAs may influence the progression of the disease by regulating immune function and inflammatory responses. This review mainly focused on miRNAs and how they contribute to gouty arthritis. It also looked at how miRNAs could be used as diagnostic, prognostic, and potential therapeutic targets.