Медицинская библиотека · The Journal of rheumatology · 2001

Serum levels of interleukin 15 in patients with rheumatic diseases.

Suzuki J, Morimoto S, Amano H, Tokano Y, Takasaki Y, Hashimoto H

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Аннотация

OBJECTIVE

The role of the cytokine interleukin 15 (IL-15) in rheumatic disease is unclear. We examined serum levels of IL-15 in patients with various rheumatic diseases.

METHODS

Serum levels of IL-15 were determined by sandwich ELISA.

RESULTS

Serum levels of IL-15 were significantly increased in patients with polymyositis/dermatomyositis, polyarteritis nodosa, and systemic sclerosis; and significantly increased as well in disease complicated by interstitial pneumonitis (IP), hemophagocytic syndrome (HPS), and/or vasculitis. Patients with serum IL-15 levels < or = 5 pg/ml showed significantly high rates of survival.

CONCLUSION

IL-15 is related to the pathogenesis of IP, HPS, and/or vasculitis. Serum IL-15 level could possibly be used as a marker of prognosis.

Для цитирования: Suzuki J, Morimoto S, Amano H, Tokano Y, Takasaki Y, Hashimoto H. Serum levels of interleukin 15 in patients with rheumatic diseases.. The Journal of rheumatology. 2001.

Предметные рубрики MeSH

Adolescent Adult Aged Biomarkers Dermatomyositis Disease Progression Enzyme-Linked Immunosorbent Assay Female Histiocytosis, Non-Langerhans-Cell Humans Interleukin-15 Lung Diseases, Interstitial Male Middle Aged Polyarteritis Nodosa Scleroderma, Systemic Vasculitis

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