Frontiers in microbiology · 2026
Bacterial distribution and drug resistance patterns of urinary tract infection in tuberculosis patients: a 5-year retrospective study.
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Shui Jian, Tan Aichun, Pan Jianhua, Shi Guomin
Аннотация
OBJECTIVE: To investigate the bacterial distribution and drug resistance profile of urinary tract infections (UTIs) in tuberculosis patients, and to provide evidence-based support for the rational clinical use of antimicrobial agents in this specific patient population.
METHODS: A retrospective analysis was performed on bacterial identification and antimicrobial susceptibility test results of tuberculosis patients complicated with UTIs in our hospital from January 2020 to December 2024. Data were processed via WHONET 5.6 and SPSS 21.0.
RESULTS: A total of 1,151 strains were isolated, including 878 Gram-negative strains (76.3%, mainly Escherichia coli 34.9% and Klebsiella pneumoniae 22.2%) and 273 Gram-positive strains (23.7%, predominantly Enterococcus faecium 15.6%). Escherichia coli showed low resistance to cefoperazone/sulbactam, amikacin, tigecycline and carbapenems (resistance rate < 5%). Klebsiella pneumoniae showed low resistance only to tigecycline (resistance rate 0%), while Enterococcus faecium showed low resistance to quinupristin/dalfopristin, linezolid, high concentrations of Streptomycin, high concentrations of Gentamicin, tigecycline and vancomycin (resistance rate < 5%). Additionally, Klebsiella pneumoniae resistance rates to multiple antimicrobials were significantly higher in male patients than in females (all p < 0.05). Severe tuberculosis patients had notably higher resistance rates of Escherichia coli to amoxicillin/clavulanate, ertapenem, and Klebsiella pneumoniae to multiple antimicrobials (all p < 0.05).
CONCLUSION: Continuous monitoring of bacterial distribution and drug resistance in tuberculosis patients with UTIs is essential to improve diagnosis and treatment accuracy and guide rational clinical medication use.
METHODS: A retrospective analysis was performed on bacterial identification and antimicrobial susceptibility test results of tuberculosis patients complicated with UTIs in our hospital from January 2020 to December 2024. Data were processed via WHONET 5.6 and SPSS 21.0.
RESULTS: A total of 1,151 strains were isolated, including 878 Gram-negative strains (76.3%, mainly Escherichia coli 34.9% and Klebsiella pneumoniae 22.2%) and 273 Gram-positive strains (23.7%, predominantly Enterococcus faecium 15.6%). Escherichia coli showed low resistance to cefoperazone/sulbactam, amikacin, tigecycline and carbapenems (resistance rate < 5%). Klebsiella pneumoniae showed low resistance only to tigecycline (resistance rate 0%), while Enterococcus faecium showed low resistance to quinupristin/dalfopristin, linezolid, high concentrations of Streptomycin, high concentrations of Gentamicin, tigecycline and vancomycin (resistance rate < 5%). Additionally, Klebsiella pneumoniae resistance rates to multiple antimicrobials were significantly higher in male patients than in females (all p < 0.05). Severe tuberculosis patients had notably higher resistance rates of Escherichia coli to amoxicillin/clavulanate, ertapenem, and Klebsiella pneumoniae to multiple antimicrobials (all p < 0.05).
CONCLUSION: Continuous monitoring of bacterial distribution and drug resistance in tuberculosis patients with UTIs is essential to improve diagnosis and treatment accuracy and guide rational clinical medication use.