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DOI 10.1126/science.adw0855

Медицинская библиотека · Science (New York, N.Y.) · 2026

Spatially resolved single-cell atlas reveals the macroevolutionary trajectory of animal hearts.

Lian Shanshan, Wang Wei, Liu Yaoxin, Lu Meina, Han Wentao, Luo Jiaxin, Zhang Xuejiao, Pang Yue, Li Yuru, Li Yufeng, Dang Xin, Wang Peiyan, Qin Yating, Tan Ning, Zhang Fang, Zhang Jin, Gao Shuai, Zhang Runyi, Guo Lidong, Jiang Lei, Zhang Pengchong, Zhang Yuehuan, Qu Zhe, Pan Shanshan, Zhang Yue, Hu Naina, Chen Yadong, Cao Yun, Li Wenbin, Chen Xiaomei, Shi Junjie, Yang Shuaiqi, Li Yiran, Song Qiuyun, Bao Lisui, Li Yuli, Liu Xiawei, Wang Jing, Zhang Lingling, Li Rui, Yu Xin, Yang Tao, Chen Jing, Li Ling, Zhang Mengqi, Li Lei, Zhang Ruihua, Li Hongyan, Gu Ying, Xu Xun, Yang Huanming, Bao Zhenmin, Burns C Geoffrey, Burns Caroline E, Kelly Robert G, Wang Jianxun, Zhao Yang, Su Ying, Fan Guangyi, Liu Qun, Wang Shi, Fei Ji-Feng, Pan Silin, Zhao Long

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Аннотация

Animal hearts display diverse anatomical structures during adaptive evolution. Here, we present a multiomics atlas of adult hearts from 27 species across chordates, arthropods, and mollusks. Joint analysis indicates that Bilateria hearts share a core gene repertoire, taking a stepwise "add-on" approach as a universal evolutionary strategy. The "proto-heart" is populated by key cell types, including cardiomyocytes, fibroblasts, endothelial cells, and neural cells, which maintained core signatures while evolving with shifts in living environments and corresponding adaptations in the cardiovascular system. Additionally, we reveal an evolutionarily conserved cardiomyocyte state dynamic potentially linked to cardiac development and stress responses. Finally, we identify a common molecular program underpinning chamber evolution from a ventricular foundation. This work establishes a resource for understanding the intrinsic mechanisms of heart evolution.

Для цитирования: Lian Shanshan, Wang Wei, Liu Yaoxin, Lu Meina, Han Wentao, Luo Jiaxin, Zhang Xuejiao, Pang Yue, Li Yuru, Li Yufeng, Dang Xin, Wang Peiyan, Qin Yating, Tan Ning, Zhang Fang, Zhang Jin, Gao Shuai, Zhang Runyi, Guo Lidong, Jiang Lei, Zhang Pengchong, Zhang Yuehuan, Qu Zhe, Pan Shanshan, Zhang Yue, Hu Naina, Chen Yadong, Cao Yun, Li Wenbin, Chen Xiaomei, Shi Junjie, Yang Shuaiqi, Li Yiran, Song Qiuyun, Bao Lisui, Li Yuli, Liu Xiawei, Wang Jing, Zhang Lingling, Li Rui, Yu Xin, Yang Tao, Chen Jing, Li Ling, Zhang Mengqi, Li Lei, Zhang Ruihua, Li Hongyan, Gu Ying, Xu Xun, Yang Huanming, Bao Zhenmin, Burns C Geoffrey, Burns Caroline E, Kelly Robert G, Wang Jianxun, Zhao Yang, Su Ying, Fan Guangyi, Liu Qun, Wang Shi, Fei Ji-Feng, Pan Silin, Zhao Long. Spatially resolved single-cell atlas reveals the macroevolutionary trajectory of animal hearts.. Science (New York, N.Y.). 2026. DOI: 10.1126/science.adw0855.

Предметные рубрики MeSH

AnimalsBiological EvolutionMultiomicsMyocardiumMyocytes, CardiacAtlases as TopicHumansMiceSpecies SpecificityTranscriptomeSingle-Cell Gene Expression Analysis
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