Immune-Mediated Neuropathies Other Than Typical Chronic Inflammatory Demyelinating Polyradiculoneuropathy-Multifocal Motor Neuropathy, Autoimmune Nodopathies, Anti-Myelin Associated Glycoprotein Neuropathy, Chronic Inflammatory Sensory Polyradiculoneuropathy, and Chronic Ataxic Neuropathy with Ophthalmoplegia, M-Protein, Agglutinin, and Disialosyl Antibodies.

A pattern recognition approach to autoimmune polyneuropathies is fundamental to an evidence-based, efficient, and cost-effective approach to the accurate diagnosis of such chronic inflammatory demyelinating polyneuropathy mimickers as multifocal motor neuropathy, autoimmune nodopathies, anti-myelin associated glycoprotein neuropathy, chronic inflammatory sensory polyradiculoneuropathy, and chronic ataxic neuropathy with ophthalmoplegia, M-protein, agglutinin, and disialosyl antibodies. Increased understanding of the IgG4 and IgG3 mediated autoimmune nodopathies represents an exciting advance in our pathomechanistic understanding of immune mediated polyneuropathy that defies the traditional axonal vs demyelinating construct, and rather, reflects targeted dysfunction of the node of Ranvier.