Diagnosis and treatment of the systemic and cutaneous necrotizing vasculitis syndromes.

Advances in understanding of the spectrum of clinical presentations of patients with systemic and cutaneous necrotizing vasculitis as well as further work on pathogenesis of these conditions has helped with diagnosis of these conditions. Therapies for systemic and cutaneous necrotizing vasculitis are based on disease extent, severity, and concomitant conditions in the individual patient. Future multicenter and multidisciplinary studies will provide improved treatments for these challenging clinical situations.