A Novel Approach to the Treatment of Familial Expansile Osteolysis: A Rare Genetic Bone Pathology: A Case Report.

CASE: Familial expansile osteolysis (FEO) is a rare inherited autosomal dominant condition causing the development of painful lytic bone lesions. We present the case of a 54-year-old man with FEO who was treated with denosumab. The patient's progress was monitored with radiographs, magnetic resonance imaging, bone turnover markers, pain, and functional scores.

CONCLUSION

The use of denosumab for FEO displays improvement in radiological appearances of the affected bone, increased quality of life and may prevent the development of further lesions. It is a safe treatment modality for patients with FEO that allows for limb salvage surgery rather than amputation.