Leptospira-associated secondary sclerosing cholangitis after acute leptospiral hepatitis.

Leptospirosis exhibits a broad spectrum of clinical symptoms, ranging from mild fever to severe multiorgan failure. Hepatic dysfunction is common in leptospirosis and typically occurs after the prodromal phase of the disease. Jaundice in leptospirosis is due to impaired hepatocellular bilirubin excretion and bile flow disruption. However, bile duct injury leading to secondary sclerosing cholangitis (SSC) in leptospirosis is rare.