Medecine tropicale et sante internationale · 2026
[Tick-borne disease in a backpacker in French Guiana: one case of presumed anaplasmosis].
СтатьяКлинический случайАннотация на английскомНазвание и аннотация: Перевод в очереди
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Bourne-Watrin Morgane, Alsibai Kinan Drak, Duron Olivier, Destoop Justin, Douine Maylis, Epelboin Loïc, Couppié Pierre
Аннотация
INTRODUCTION: New species of Borrelia, Rickettsia, and Anaplasma have recently been detected in ticks in French Guiana. Additionally, a new species of Anaplasma was discovered in a human. Specific genovariants of Anaplasma and Ehrlichia have also been identified in the Amazonian forest of French Guiana, indicating a specific sylvatic cycle.
CASE PRESENTATION: We present the case of a patient who experienced fever, myalgia, rash, and inoculation eschars following dozens of tick bites while hiking in the Amazon rainforest. Laboratory results showed lymphopenia, neutrophilia, hepatic cytolysis and cholestasis, and a C-reactive protein level of 78 mg/L. Serology tests for HIV, hepatitis A, B, C, and E; cytomegalovirus; syphilis; and Q fever were negative. NS1 antigen, dengue, and leptospirosis PCR tests were also negative. A skin biopsy of an ulcerated papule on the leg revealed a polymorphic dermal inflammatory infiltrate with intramacrophagic Gram-negative bacilli. Blood PCR for Anaplasma phagocytophilum, Borrelia, Rickettsia, and Babesia were negative. Serology tests were negative for Rickettsia conorii and R. typhi, but positive for A. phagocytophilum, with weakly positive IgM and positive IgG. Serological results were confirmed by controlled sample. The patient improved with doxycycline treatment.
DISCUSSION AND CONCLUSION: Novel species of Anaplasma and Ehrlichia have been detected in the Amazon rainforest of French Guiana. These novel genovariants differ from other species in the Northern Hemisphere and are difficult to diagnose with molecular tools not designed to detect pathogens differing from known species. While not proven by molecular biology, this case may represent an anaplasmosis or another infection from the Rickettsiales group. This highlights that little is known about the potential for tick-borne diseases in French Guiana. In this context, recommendations for vector control should extend to ticks as well.
CASE PRESENTATION: We present the case of a patient who experienced fever, myalgia, rash, and inoculation eschars following dozens of tick bites while hiking in the Amazon rainforest. Laboratory results showed lymphopenia, neutrophilia, hepatic cytolysis and cholestasis, and a C-reactive protein level of 78 mg/L. Serology tests for HIV, hepatitis A, B, C, and E; cytomegalovirus; syphilis; and Q fever were negative. NS1 antigen, dengue, and leptospirosis PCR tests were also negative. A skin biopsy of an ulcerated papule on the leg revealed a polymorphic dermal inflammatory infiltrate with intramacrophagic Gram-negative bacilli. Blood PCR for Anaplasma phagocytophilum, Borrelia, Rickettsia, and Babesia were negative. Serology tests were negative for Rickettsia conorii and R. typhi, but positive for A. phagocytophilum, with weakly positive IgM and positive IgG. Serological results were confirmed by controlled sample. The patient improved with doxycycline treatment.
DISCUSSION AND CONCLUSION: Novel species of Anaplasma and Ehrlichia have been detected in the Amazon rainforest of French Guiana. These novel genovariants differ from other species in the Northern Hemisphere and are difficult to diagnose with molecular tools not designed to detect pathogens differing from known species. While not proven by molecular biology, this case may represent an anaplasmosis or another infection from the Rickettsiales group. This highlights that little is known about the potential for tick-borne diseases in French Guiana. In this context, recommendations for vector control should extend to ticks as well.