Respiratory investigation · 2025
Desaturation in the six-minute walk test predicts progressive pulmonary fibrosis in fibrotic interstitial lung disease.
СтатьяНазвание и аннотация: Перевод в очереди
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Takei Reoto, Fukihara Jun, Yamano Yasuhiko, Kataoka Kensuke, Kimura Tomoki, Watanabe Fumiko, Furukawa Taiki, Fukuoka Junya, Johkoh Takeshi, Kondoh Yasuhiro
Аннотация
BACKGROUND: The 6-min walk test (6MWT) is a widely used functional test that assesses desaturation on exercise. However, the clinical impact of desaturation on progressive pulmonary fibrosis (PPF) has been insufficiently studied. We aimed to evaluate the association between desaturation and future progression in patients with fibrotic interstitial lung disease (FILD).
METHODS: We retrospectively analysed consecutive patients with FILD from 2008 to 2015. Desaturation was defined as oxygen saturation measured by pulse oximetry (SpO2) at the end of the 6MWT being less than 90 %. It was divided into two groups: mild (SpO2 was 89 %) and moderate desaturation (SpO2 was 88 % or less).
RESULTS: Among 810 patients, 498 (61.5 %) had desaturation (45 mild and 453 moderate). Multivariable Cox proportional hazard analysis showed desaturation was associated with a higher mortality (HR: 1.69, 95 % CI: 1.37-2.08, p < 0.0001). Both mild and moderate desaturation were also associated with a higher mortality compared with no desaturation, although there was no significant difference between them. Multivariable logistic regression analysis showed that desaturation was associated with PPF in the overall cohort (OR: 2.20, 95 % CI: 1.59-3.05, p < 0.0001), in patients with idiopathic pulmonary fibrosis (IPF) (OR: 2.59, 95 % CI: 1.56-4.29, p = 0.0002), and in patients with non-IPF FILD (OR: 1.86, 95 % CI: 1.17-2.96, p = 0.0091).
CONCLUSIONS: Desaturation in the 6MWT was associated with future risk of progression in patients with newly diagnosed FILD.
METHODS: We retrospectively analysed consecutive patients with FILD from 2008 to 2015. Desaturation was defined as oxygen saturation measured by pulse oximetry (SpO2) at the end of the 6MWT being less than 90 %. It was divided into two groups: mild (SpO2 was 89 %) and moderate desaturation (SpO2 was 88 % or less).
RESULTS: Among 810 patients, 498 (61.5 %) had desaturation (45 mild and 453 moderate). Multivariable Cox proportional hazard analysis showed desaturation was associated with a higher mortality (HR: 1.69, 95 % CI: 1.37-2.08, p < 0.0001). Both mild and moderate desaturation were also associated with a higher mortality compared with no desaturation, although there was no significant difference between them. Multivariable logistic regression analysis showed that desaturation was associated with PPF in the overall cohort (OR: 2.20, 95 % CI: 1.59-3.05, p < 0.0001), in patients with idiopathic pulmonary fibrosis (IPF) (OR: 2.59, 95 % CI: 1.56-4.29, p = 0.0002), and in patients with non-IPF FILD (OR: 1.86, 95 % CI: 1.17-2.96, p = 0.0091).
CONCLUSIONS: Desaturation in the 6MWT was associated with future risk of progression in patients with newly diagnosed FILD.