Evaluating the Efficacy of Ozone Therapy in Fibromyalgia.

Fibromyalgia is a chronic disorder, characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and psychological distress, with limited efficacy from conventional treatments. Ozone therapy, a medical approach that induces controlled oxidative stress to enhance antioxidant defences and modulate immune responses, has emerged as a potential complementary intervention. Evidence suggests that ozone therapy improves pain, fatigue, and sleep quality by correcting oxidative imbalances, enhancing oxygen utilization, and regulating inflammatory pathways. Clinical studies, report significant symptom relief in up to 70% of patients, with minimal adverse effects when administered according to standardized protocols. Despite promising outcomes, the current literature is constrained by small sample sizes, heterogeneity in study designs, and limited long-term follow-up data. Future research should focus on large-scale, well-designed trials, standardized treatment protocols, and mechanistic studies to establish ozone therapy's role in fibromyalgia management.