Zhurnal mikrobiologii, epidemiologii i immunobiologii · 2007
[Immunogenicity of surface and capsular antigens of Burkholderia].
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Piven' N N, Avrorova I V, Zhukova S I, Alekseev V V, Khrapova N P, Korsakova I I, Lomova L V, Napalkova G M, Drefs I M, Proshina O B
Аннотация
Study showed that five (C3, C6, C9, C10, C11) out of ten chromatographic fractions of surface and capsular antigens of B. mallei significantly stimulated cell-mediated immunity that manifested in activation of delayed hypersensivity reactions (DHS) and phagocyteability of noncapsulated avirulent strain of B. mallei with added surface and capsular antigenic complexes. Other fractions did not stimulate cell-mediated immunity, furthermore, fraction C8, which contained capsular biopolymer with mass of 200 kD (Ar8), was characterized by immunosuppressive effect on DHS and phagocytosis. Observed stimulation of cell-mediated immunity by fractions referred above has been confirmed by assessment of their protective effects on the model of experimental melioidosis in white rats. Relationship between markers of humoral and cell-mediated immunity, including markers of specific response, was not observed.