Vav3, a potential diagnostic and prognostic marker of diabetes, regulates glycolipid metabolism.

Vav3 can significantly affect the energy metabolism of cancer cells by changing the cytoskeletal structure, involving the mechanism of disulfidptosis, while affecting the function of glucose transporters, regulating cellular glucose and lipid metabolism. This provides an interesting research idea for the exploration of the pathogenesis of diabetes and the targeted regulation of glucose and lipid metabolism. Vav3 protein not only participates in β-cell damage in type 1 diabetes but also extensively regulates insulin release and glucose metabolism in type 2 diabetes. Vav3 proteins directly or indirectly regulate energy metabolism in multiple organs such as the pancreas, skeletal muscle, and liver and are involved in some pathological processes such as oxidative stress, inflammation, and autophagy. These pathological processes are not only regulated by the Vav3 protein, but also in turn affect the expression level of the Vav3 gene, exacerbating the progression of diabetic complications such as diabetic osteoporosis and even diabetes-related cancers. Therefore, the regulated molecular patterns of Vav3 in the microenvironment of diabetic glucose and lipid metabolism disorder provide a new direction for further exploration of diabetic energy metabolism mechanism. Vav3 may be a potential diagnostic and prognostic marker of diabetes. Meanwhile, as an oncogene, it also builds a bridge and increases the depth of the connection between diabetes and cancer.