Piezo 1 and Shear-induced Erythrocyte Transformation and Procoagulant Activity: Implication for LVAD-Induced Bleeding.

OBJECTIVE

To explore the biosample donation intentions and its influencing factors of infectious disease patients based on the Theory of Planned Behavior so as to provide references for formulating publicity strategy to improve patients' awareness of donating biosamples and assist in the construction of infectious disease biobank.

METHODS

By applying the phenomenological research method of qualitative research and using purposive sampling, 15 patients with infectious diseases who were hospitalized in a infectious disease hospital in Jiangsu Province from February to April 2025 were selected for semi-structured interviews. The interview data were collated and analyzed using Nvivo12.0 software and Colaizzi analysis methods.

RESULTS

A total of 3 themes and 8 sub-themes were extracted. The themes including: patients with infectious diseases had different attitudes towards biosample donation intentions (positive attitude for donating behaviour were meaningful, negative attitude for no benefit to themselves, and neutral attitude for the unknown risks of donating behaviour); driven by multifaceted subjective norms (family support, medical staff intervention, and social concepts); the perceptual behavioral control was limited (multiple concerns such as privacy protection, research institutions, informed parties, types of donated samples, feedback on research results, costs and compensation, etc).

CONCLUSION

The biosample donation intention of infectious disease patients is influenced by multiple factors. Appropriate and targeted publicity strategies should be formulated, such as differentiated health education for patients with positive/negative/neutral attitudes, and leveraging the guiding role of family members and healthcare providers to enhance patients' recognition of biosample donation behaviour, give more play to the potential driving role of family, medical staff and social support, explore reasonable and effective informed consent model therefore to assist in the scientific research of infectious diseases and the construction of infectious disease biobank.