Metabolic syndrome in postmenopausal women with osteoporosis and its relationship with bone density and turnover markers.

INTRODUCTION

Previous research has explored the uncertain association between metabolic syndrome (MetS) and bone mineral density (BMD). The objective of this study was to determine the prevalence of MetS in postmenopausal Moroccan women with osteoporosis and to examine the relationship between MetS, BMD, and bone turnover markers among this sample.

MATERIAL AND

METHODS

This was a cross-sectional study of 100 postmenopausal women. Anthropometric parameters and biochemical blood tests were assessed. Bone mineral density and T-scores in the lumbar spine and femoral neck were screened. Bone mineral density was determined using dual-energy X-ray absorptiometry. National Cholesterol Education Program-Adult Treatment Panel III criteria were used to define MetS. The association between the MetS components, BMD, and bone turnover markers was evaluated by partial correlation and multiple linear regression analysis using SPSS software.

RESULTS

Prevalence of MetS in our patients was 44%. The mean age of patients with and those without MetS was 63.82 ±8.65 and 60.39 ±7.93, respectively; p = 0.04. Lumbar spine BMD correlated significantly with high-density lipoprotein cholesterol (HDL-C; r = -0.233; p = 0.02). Lumbar spine T-score correlated with systolic blood pressure (SBP; r = -0.196; p = 0.005) and waist circumference (r = 0.274; p = 0.006). Femoral neck T-score correlated with diastolic blood pressure (r = -0.218; p = 0.02) and waist circumference (r = 0.294; p = 0.003). Osteocalcin inversely correlated with HDL-C and fasting plasma glucose (r = -0.199; p = 0.04 and r = -0.238; p = 0.01 respectively). Carboxy-terminal cross-linked telopeptide of type I collagen correlated negatively with HDL-C and SBP (r = -0.238; p = 0.02 and r = -0.243; p = 0.01 respectively). After linear regression, lumbar spine BMD was associated with age (β = -2.120, p = 0.04), SBP (β = -0.112, p = 0.01) and waist circumference (β = 0.253, p = 0.001). Femoral neck BMD was associated with age (β = -0.227, p = 0.02) and waist circumference (β = 0.258, p = 0.008).

CONCLUSIONS

The prevalence of MetS was associated with osteoporosis in postmenopausal Moroccan women, predominantly driven by age, blood pressure, and central obesity.