Медицинская библиотека · Cytokine · 2012

Pilot study of interleukin-27 in pathogenesis of dermatomyositis and polymyositis: associated with interstitial lung diseases.

Shen Hui, Xia Liping, Lu Jing

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

OBJECTIVE

To determine whether interleukin (IL)-27 is involved in dermatomyositis (DM) and polymyositis (PM).

METHODS

Serum IL-27, IL-18 and interferon-γ (IFN-γ) levels in 37 DM and 15 PM were detected by enzyme-linked immunosorbent assay (ELISA).

RESULTS

Serum IL-27, IL-18 and IFN-γ levels were significantly higher in DM and PM patients than in healthy controls. Significant higher levels of IL-27 were found in high creatine kinase (CK) level group and in patients with interstitial lung disease (ILD). Level of IL-27 was correlated with global 100-mm visual analog scales (VASs) score in patients with PM.

CONCLUSION

These data supports the hypothesis that IL-27 maybe involved in DM and PM pathogenesis.

Для цитирования: Shen Hui, Xia Liping, Lu Jing. Pilot study of interleukin-27 in pathogenesis of dermatomyositis and polymyositis: associated with interstitial lung diseases.. Cytokine. 2012. DOI: 10.1016/j.cyto.2012.07.011.

Предметные рубрики MeSH

Adult Case-Control Studies Creatine Kinase Dermatomyositis Female Humans Interferon-gamma Interleukin-18 Interleukins Lung Diseases, Interstitial Male Middle Aged Pain Measurement Pilot Projects Polymyositis

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