Molecular neurobiology · 2025
Analgesic Effects of Acupressure on Jing-jiaji Acupoints in a Rat Model of Cervical Spondylotic Radiculopathy.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Jiang Shang-Hong, Yang Song, Meng Ling, Xie Ling-Yao, Yang Jia-Ni, Li Si-Qi, Liao Ke-Ying, Qiu Zhi-Fang, Xiao Yao-Yao, Fu Man-Di, Liu Zhi-Li, Jiang Xue-Yu
Аннотация
BACKGROUND: Cervical spondylotic radiculopathy (CSR) is increasingly prevalent, causing neck pain and radiating symptoms. As alternatives to surgery, acupressure stimulation of Jing-jiaji acupoints therapies have gained traction albeit lacking evidence.
METHODS: Rats underwent spinal cord compression modeling CSR or sham surgery, alongside normal controls. A week post-surgery, CSR rats underwent no intervention or standardized acupressure of Jing-jiaji acupoints at 2, 4 or 6N. Sensory, locomotor and electrophysiological functions were assessed along with tissue analyses for pain mediators.
RESULTS: Relative to sham group, untreated CSR rats exhibited mechanical/pressure pain hypersensitivity, gait impairments, slowed nerve conduction velocities and reduced sensory evoked potentials, accompanied by heightened spinal inflammation and neuronal damage. Acupressure markedly attenuated these neuropathic CSR manifestations in a stimulus-dependent manner, with maximal therapeutic efficacy observed at 4-6N intensity.
CONCLUSION: This study demonstrates bilateral acupressure stimulation of neck Jing-jiaji acupoints to effectively mitigate characteristic neurogenic pain and neurological dysfunction in a rodent CSR model.
METHODS: Rats underwent spinal cord compression modeling CSR or sham surgery, alongside normal controls. A week post-surgery, CSR rats underwent no intervention or standardized acupressure of Jing-jiaji acupoints at 2, 4 or 6N. Sensory, locomotor and electrophysiological functions were assessed along with tissue analyses for pain mediators.
RESULTS: Relative to sham group, untreated CSR rats exhibited mechanical/pressure pain hypersensitivity, gait impairments, slowed nerve conduction velocities and reduced sensory evoked potentials, accompanied by heightened spinal inflammation and neuronal damage. Acupressure markedly attenuated these neuropathic CSR manifestations in a stimulus-dependent manner, with maximal therapeutic efficacy observed at 4-6N intensity.
CONCLUSION: This study demonstrates bilateral acupressure stimulation of neck Jing-jiaji acupoints to effectively mitigate characteristic neurogenic pain and neurological dysfunction in a rodent CSR model.