Journal of bone and mineral metabolism · 2025
Cardiovascular safety of osteoanabolic agents.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Takeuchi Yasuhiro
Аннотация
PURPOSE: Several osteoanabolic agents have been developed to build new bone more efficiently than anti-resorptive drugs. Among them, romosozumab, an anti-sclerostin antibody, is a potent pharmacological tool to prevent fractures in osteoporosis patients. The efficacy of romosozumab in preventing osteoporotic fractures is robust. However, there remains a concern about increased cardiovascular (CV) adverse events related to romosozumab. Available data have been reviewed to address this concern.
METHODS: Published articles on romosozumab of which pivotal randomized controlled trials (RCTs), meta-analyses of RCTs, pharmacovigilance investigations, and retrospective observational clinical studies using real-world data were collected through PubMed and other available tools.
RESULTS: Meta-analyses of RCTs of romosozumab compared to placebo and other anti-osteoporosis drugs have left room for controversy in the CV safety of romosozumab. Investigations of the real-world data also provide no conclusive evidence in this issue.
CONCLUSION: We need more robust evidence to establish an appropriate and reasonable guide to prescribe romosozumab in our clinical practice.
METHODS: Published articles on romosozumab of which pivotal randomized controlled trials (RCTs), meta-analyses of RCTs, pharmacovigilance investigations, and retrospective observational clinical studies using real-world data were collected through PubMed and other available tools.
RESULTS: Meta-analyses of RCTs of romosozumab compared to placebo and other anti-osteoporosis drugs have left room for controversy in the CV safety of romosozumab. Investigations of the real-world data also provide no conclusive evidence in this issue.
CONCLUSION: We need more robust evidence to establish an appropriate and reasonable guide to prescribe romosozumab in our clinical practice.