BMC infectious diseases · 2025
Disseminated Talaromyces marneffei infection in a patient with Ankylosing Spondylitis: a case report and review of the literature.
СтатьяКлинический случайОбзорНазвание и аннотация: Перевод в очереди
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Wang Yaoqin, Liang Meichun, Hu Meina, Mao Guofeng
Аннотация
BACKGROUND: Ankylosing Spondylitis (AS) is a prevalent autoimmune disorder that necessitates the prolonged use of corticosteroids, non-steroidal anti-inflammatory drugs (NSAIDs), and disease-modifying antirheumatic drugs (DMARDs). Immunosuppressive medications are now commonly incorporated into treatment plans; however, this may increase patients' risk of severe infections. Infections caused by Talaromyces marneffei (TM) are rarely seen in patients with AS, yet if left untreated, they could result in severe morbidity and even death.
CASE REPORT: This report presents a comprehensive case study of a 44-year-old Human Immunodeficiency Virus (HIV)-negative male with Ankylosing Spondylitis (AS) complicated by diabetes mellitus, who developed both soft tissue and pulmonary infections. Initial diagnosis suggested a bacterial etiology; however, clinical response to broad-spectrum antibiotics was suboptimal. Subsequent diagnostic procedures, including biopsy and culture of axillary lymph nodes and pulmonary tissue, coupled with Metagenomic Next-Generation Sequencing (mNGS), confirmed the diagnosis of disseminated TM infection. The patient achieved favorable outcomes following targeted antifungal therapy.
CONCLUSION: Patients with compromised immune function due to chronic immunosuppressive treatments require vigilant monitoring for uncommon opportunistic pathogens, particularly fungal infections. Advanced diagnostic techniques for early identification of pathogens, prompt and accurate prescription of antimicrobial agents, tailored dosing schedules, and stringent monitoring for potential complications are crucial for optimizing patient outcomes.
CASE REPORT: This report presents a comprehensive case study of a 44-year-old Human Immunodeficiency Virus (HIV)-negative male with Ankylosing Spondylitis (AS) complicated by diabetes mellitus, who developed both soft tissue and pulmonary infections. Initial diagnosis suggested a bacterial etiology; however, clinical response to broad-spectrum antibiotics was suboptimal. Subsequent diagnostic procedures, including biopsy and culture of axillary lymph nodes and pulmonary tissue, coupled with Metagenomic Next-Generation Sequencing (mNGS), confirmed the diagnosis of disseminated TM infection. The patient achieved favorable outcomes following targeted antifungal therapy.
CONCLUSION: Patients with compromised immune function due to chronic immunosuppressive treatments require vigilant monitoring for uncommon opportunistic pathogens, particularly fungal infections. Advanced diagnostic techniques for early identification of pathogens, prompt and accurate prescription of antimicrobial agents, tailored dosing schedules, and stringent monitoring for potential complications are crucial for optimizing patient outcomes.