Annals of work exposures and health · 2026
Association of oil spill-related volatile organic compound exposure with CVD-related biomarkers in the Gulf Long-term Follow-up Study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Patel Opal P, Edwards Jessie K, Kucharska-Newton Anna M, Whitsel Eric A, Christenbury Kate, Jackson W Braxton, Lawrence Kaitlyn G, Stewart Patricia A, Stenzel Mark R, Sandler Dale P, Engel Lawrence S
Аннотация
BACKGROUND: During the Deepwater Horizon disaster in 2010, oil spill response and cleanup (OSRC) workers were exposed to crude oil, including benzene, toluene, ethylbenzene, xylene, and n-hexane (BTEX-H). Growing evidence links these exposures to cardiovascular disease (CVD). Lipid and C-reactive protein levels are used to assess CVD risk and may serve as mediators of the observed associations with CVD. However, few studies have assessed associations of oil spill cleanup-related exposures with blood levels of lipids and C-reactive protein (CRP).
OBJECTIVE: This study examined associations of oil spill cleanup-related exposure to each individual BTEX-H chemical, total (aggregate sum) BTEX-H, and the BTEX-H mixture with blood lipids and CRP among OSRC workers in the Gulf Long-term Follow-up (GuLF) Study.
METHODS: Subjects comprised 2,544 OSRC workers who completed a home visit (May 2011 to May 2013) and had CVD biomarker measurements. Cumulative exposures to BTEX-H (ppb-days) were estimated using a job-exposure matrix that linked air measurements with self-reported Deepwater Horizon work histories. Study biomarkers were lipids, including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol, and high-sensitivity CRP (hsCRP), which were measured in blood samples collected during the home visit. Multivariable linear regression was used to estimate mean differences and 95% confidence intervals (CI) for associations of quartiles of BTEX-H with lipid and hsCRP levels. We log-transformed hsCRP due to a non-normal distribution. We used quantile g-computation to assess the joint effect of the BTEX-H mixture.
RESULTS: Each BTEX-H chemical was associated with elevations in total cholesterol up to 3 yr after exposure, with the strongest effect estimates in the top quartile, ranging from 2.3 to 5.1 mg/dL. A one quartile simultaneous increase in the BTEX-H mixture was associated with a 1.7 mg/dL increase in total cholesterol. While trends were less consistent for hsCRP, most estimates were above the null and a one quartile increase in exposure to the BTEX-H mixture was associated with a 3% increase in hsCRP.
CONCLUSION: Our study suggests that oil spill cleanup-related BTEX-H exposures were associated with elevations in some CVD biomarkers.
OBJECTIVE: This study examined associations of oil spill cleanup-related exposure to each individual BTEX-H chemical, total (aggregate sum) BTEX-H, and the BTEX-H mixture with blood lipids and CRP among OSRC workers in the Gulf Long-term Follow-up (GuLF) Study.
METHODS: Subjects comprised 2,544 OSRC workers who completed a home visit (May 2011 to May 2013) and had CVD biomarker measurements. Cumulative exposures to BTEX-H (ppb-days) were estimated using a job-exposure matrix that linked air measurements with self-reported Deepwater Horizon work histories. Study biomarkers were lipids, including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol, and high-sensitivity CRP (hsCRP), which were measured in blood samples collected during the home visit. Multivariable linear regression was used to estimate mean differences and 95% confidence intervals (CI) for associations of quartiles of BTEX-H with lipid and hsCRP levels. We log-transformed hsCRP due to a non-normal distribution. We used quantile g-computation to assess the joint effect of the BTEX-H mixture.
RESULTS: Each BTEX-H chemical was associated with elevations in total cholesterol up to 3 yr after exposure, with the strongest effect estimates in the top quartile, ranging from 2.3 to 5.1 mg/dL. A one quartile simultaneous increase in the BTEX-H mixture was associated with a 1.7 mg/dL increase in total cholesterol. While trends were less consistent for hsCRP, most estimates were above the null and a one quartile increase in exposure to the BTEX-H mixture was associated with a 3% increase in hsCRP.
CONCLUSION: Our study suggests that oil spill cleanup-related BTEX-H exposures were associated with elevations in some CVD biomarkers.