[On "2015 Guidelines for Prevention and Treatment of Osteoporosis". Organ-network failure as a cause for osteoporosis].

The discovery of organ-network between bone and other organs revealed that organs other than bone are intimately involved in bone remodeling. Notably, control of bone remodeling by nervous system and control of phosphate and glucose metabolism by bone are areas of intense investigation. Moreover, metabolic diseases such as diabetes and COPD are shown to be involved in the pathogenesis of osteoporosis. Thus, osteoporosis is considered to be not just a local bone disease, but a manifestation of the whole body metabolism abnormality.