Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) · 2025
[Poor prognostic factors in rheumatoid arthritis patients].
СтатьяНаблюдательное исследованиеАннотация на английскомНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
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Hernández-Morales María Del Rocío, Garcia-Vences Edna Elisa, García-López César Leonardo, Castellanos-Guerrero Ana Karen, Cristóbal-Jiménez Pedro, Rojas-Guzmán Itzel Victoria
Аннотация
OBJECTIVE: To determine the factors associated with a poor prognosis in patients with RA at a 3rd level hospital.
METHODS: Observational, analytical, longitudinal study of a cohort of patients with RA. The study continued for one year. The following were assessed as PPFs: sex, comorbidities, smoking, DAS 28 (disease activity), ESR (erythrocyte sedimentation rate), CRP (C-reactive protein), ACCP (anti-citrullinated peptide antibody), RF (rheumatoid factor), and bone erosions. To statistical analysis: A Cox proportional hazards analysis was performed to analyze PPFs.
RESULTS: A total of 260 patients were included, 26 failures and 234 censored, predominantly female sex, mean age 47 ± 11.7 years, the PPFs were: ACCP, late start of DMARD, and smoking. ACCP positive have 5.8 times the risk of escalating treatment, late DMARD have 4.6 times and those who smoked 7.7 times the risk.
CONCLUSIONS: Defining the PPFs remains a great challenge for researchers, however, it is imperative to identify them to predict the response to treatment and thus limit the functional and life damage of patients.
METHODS: Observational, analytical, longitudinal study of a cohort of patients with RA. The study continued for one year. The following were assessed as PPFs: sex, comorbidities, smoking, DAS 28 (disease activity), ESR (erythrocyte sedimentation rate), CRP (C-reactive protein), ACCP (anti-citrullinated peptide antibody), RF (rheumatoid factor), and bone erosions. To statistical analysis: A Cox proportional hazards analysis was performed to analyze PPFs.
RESULTS: A total of 260 patients were included, 26 failures and 234 censored, predominantly female sex, mean age 47 ± 11.7 years, the PPFs were: ACCP, late start of DMARD, and smoking. ACCP positive have 5.8 times the risk of escalating treatment, late DMARD have 4.6 times and those who smoked 7.7 times the risk.
CONCLUSIONS: Defining the PPFs remains a great challenge for researchers, however, it is imperative to identify them to predict the response to treatment and thus limit the functional and life damage of patients.