Bulletin of experimental biology and medicine · 2025
Arginase-1 and Mer Tyrosine Kinase Expression in Monocyte Populations in Patients with Axial Spondyloarthritis.
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Sakhno L V, Shevela E Ya, Tyrinova T V, Leplina O Yu, Tikhonova M A, Morenkova A Yu, Chumasova O A, Ilyina N A, Shkaruba N S, Sizikov A E, Kurochkina Yu D, Fedorova A V, Omelchenko V O, Letyagina E A, Korolev M A, Chernykh E R
Аннотация
Axial spondyloarthritis is characterized by activation of innate immune cells, which manifested in elevation of classical monocytes and predominance of the proinflammatory phenotype. However, the immunosuppressive potential of monocyte/macrophages remains practically unexplored. We evaluated the expression of Mer tyrosine kinase (MerTK) and arginase-1 (Arg1) in monocyte subsets in patients with axial spondyloarthritis, considering different clinical features. The expression of MerTK and Arg1 in intermediate and non-classical monocytes from patients with axial spondyloarthritis was reduced in comparison with the normal. The most pronounced decrease in monocyte expression of MerTK and Arg1 was associated with a more aggressive course of the disease (presence of coxitis, high disease activity, HLA-B27 positivity) and lack of response to conventional therapy. These data demonstrate an important role of MerTK and Arg1 in limiting myeloid-driven inflammation.