Physical and mental health impact of perimenopause, menopause and post menopause in a diverse global population (MARIE Project- Global Chapter WP 2a): cross-sectional quantitative data from a mixed-methods study.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Delanerolle Gayathri, Pathiraja Vindya, Eleje George Uchenna, Toh Teck Hock, Rathnayake Nirmala, Tweneboah-Koduah Fred, Afful-Minta Nana, Mudalige Tharanga, Sun Jie, Dhanarisi Jeevan, Al-Kharusi Lamya, Al-Riyami Nihal, Mbwele Bernard, Madan-Aggarwal Ieera, Ikwuka David Chibuike, Wang Xiaorui, Mitra Pradip K, Irfan Muhammad, Kareem Rabia, Benetti-Pinto Crisitina, Dangal Ganesh, Taylor Julie, Briggs Paula, Saraswat Lucky, Hinchliff Sharron, Potocnik Kristina, Elliot Kathryn, Panay Nick, Atkinson Carol, Talaulikar Vikram, Umeoranefo Isaiah Chukwuebuka, Fontana Donatella, Kemp Helen Felicity, Corkhill Victoria, Majumder Kingshuk, Egwuatu Emmanuel Chukwubuikem, Njoku Chukwuemeka Chidindu, Rabiu Ayyuba, Chimbo Chijioke, Ezenkwele Eziamaka Pauline, Malachy Divinefavour Echezona, Eleje Lydia Ijeoma, Ndukwe Chinedu Onwuka, Oriji Sunday Onyemaechi, Chikezie Raphael Ugochukwu, Enweani-Nwokelo Ifeoma Bessie, Ezeora Nnanyelugo Chima, Ikpeze Odigonma Zinobia, Nweze Sylvester Onuegbunam, Osunkwo Assumpta Chiemeka, Edeh Gabriel Chidera, John Esther Ogechi, Obi Kenechukwu Ezekwesili, Ekwuazi Kingsley Emeka, Egbonnaji Nnenna Josephine, Ogbonna Ugoy Sonia, Muhammad Halima Bashir, Agu Kingsley Chukwuebuka, Chidozie Chiamaka Perpetua, Okoye Odili Aloysius, Okoro Chukwuemeka Chukwubuikem, Mbachu Ikechukwu Innocent, Ikechebelu Joseph Ifeanyichukwu, Onubogu Chinyere Ukamaka, Nwaogu Kingsley Chidiebere, Obiegbu Nnaedozie Paul, Nnabuchi Obinna Kenneth, Nweje Sussan, Adedayo Oludolamu Oluyemesi, Kumuyi Babatunde Rufus, Akanni Oluwasegun Ajala, Enyinna Perpetua Kelechi, Alfa Yusuf, Otis Theresa Nneoma, Otis Michael Nnanna, Agbo Chidiebere, Anigwe Francis Chibuike, Anyaeche Chidimma Judith, Okonkwo Olisaemeka Nnaedozie, Okemeziem Bethel Chinonso, Uwakwe Bethel Nnaemeka, Igboabuchi Goodnews Ozioma, Ndubuisi Ifeoma Francisca, Nkemdirim Amarachi Pearl, Sundarapperuma Thamudi, Herath Prasanna, Dassanayake Damayanthi, Herath Chandrani, Wijamuni Nimesha, Palihawattha Thinupa, Illesinghe Pramuditha, Ambepitiya Dilini, Peris Kaushini, Sitheja Vindula, Kannangara Wedura, Thavalingum Poushika, Dulanjala Achini, Gayani Pramila, Madushika Hasiduni, Sivakumar Abirami, Madhushani Chamodi Kaushalya, Keerthisinghe Chathurangika, Hathurusinghe Hasini Nimeshika, Mudalige Umanda, Lee Kim-Yen, Aiman Ali Madinah Siti Nurul, Jaafar Nurul Amalina, Wong Xiu-Sing, Yen-Sing Lee John, Lau Yee-Theng, Mohsin Alyani Mohamad, Mohd Nasir Nor Fareshah, Suk-Chin Law Diana, Zamri Farhawa, Abidin Artini, Azmi Aini Hanan, Kahar Rosdina Abd, Adnan Fatin Imtithal, Wong Xin-Sheng, Lim Geok-Seim, Yien-Mei Sim Eunice, Cristelle Karen, Haslan Asma' Mohd, Patah Noorhazliza Abdul, Nalathambi Vaitheswariy Rao, Jaafar Juhaida, Wong Lee Leong, Ibrahim Nurfauzani, Ting Sing-Yew, Chen-Ling Lo Susan, Hamdan Norhazura, Ngu Min-Huang, Dahian Safilah, Leong-Hoe Ngu Daniel, Khoo Sing-Yee, Mathur Manisha, Puvanendran Rukshini, Safdar Farah, Kathirvel Rajeswari, Aiyappan Raksha, Yela Daniela Angerame, Rezende Gabriela Pravatta, Nakamura Renan Massao, Prasad Bharat, Noor Shaziya, Shilpa Kumari, Singh Poonam, Chatterjee Manu, Mahinyila Oscar, Shemdoe Alosisia, Mpangala Kornelio, Mwahi Baraka Godfrey, Pembe Zepherine, Kaminyoge Mpoki, Alon Thomas, Mwabenga Clement, Pierre Gafaranga Jean, Clementine Kanazayire, Chinwe Nwankwo Helen, Olubiyi Bisola Folusho, Sani Nasiru, Amalimeh Benedict Erhite, Nwanna Uchechukwu Kevin, Usman Ibe Michael, Isingizwe Stella Matutina, Hanyurwimfura Jean Damascene, Marie Vianney Kabutare Jean, Uwimpuhwe Dorcas, Melanie Maombi, Kantarama Ange, Tuyisenge Elius, Habimana Emmanuel, Vaidyanathan Gowri, Al Maqrashi Maryam, Bouchareb Yassine, Shi Jian Qing, Elneil Sohier, Phiri Peter
Аннотация
METHODS: The MARIE WP2a project is a mixed-methods study that aimed to explore menopausal health across 13 countries. Study conducted from January 2024 to September 2025. Eligible participants (cis and transgender women) experiencing perimenopause, menopause, or post-menopause were recruited digitally from clinical and community settings from UK, Rwanda, Nigeria, Ghana, Tanzania, Sri Lanka, India, Pakistan, Nepal, Malaysia, Singapore, Oman and Brazil. Here, we report the quantitative component of the broader mixed-methods study within MARIE WP2a. The present analysis focuses exclusively on cross-sectional quantitative data to characterise symptom burden and associated health domains across participating countries. The primary aim of MARIE WP2a was to explore and document the physical and mental health impacts of perimenopause, menopause, and post-menopause among women. Secondary aims included exploratory assessment of symptom patterns in a subset of participants with repeated observations in the change in symptoms, lower-back pain, and quality of life. Symptom burden was assessed using validated scales covering psychological, somatic, pain, sleep, disability, and quality-of-life domains. Analyses included multivariable linear models; analyses involving repeated observations were conducted as sensitivity analyses only and, country-grouped heterogeneity models, and Gaussian Graphical Modelling to examine symptom interconnections.
FINDINGS: A total of 5228 participants from 13 countries were included. The median age was 55 years (IQR 50-61). The distribution of menopausal stages was 18.6% (n = 972) perimenopause, 32.2% (n = 1684) menopause, and 49.2% (n = 2572) post-menopause. Symptom burden varied substantially across countries and menopausal stages. The UK and Rwanda exhibited the highest levels of anxiety, depression, somatic burden, vasomotor symptoms, and overall MRS scores, while Nepal, Sri Lanka, Malaysia, and Singapore consistently showed lower burden. Clinical complexity including endometriosis, disability, long-term conditions, premature ovarian insufficiency, and GnRH analogue use was strongly associated with worse outcomes. Burnout emerged as the most central symptom connecting psychological and somatic domains.
INTERPRETATION: Menopause is a complex biopsychosocial transition shaped by geography, social determinants, and multimorbidity. Rather than testing causal hypotheses, this analysis is descriptive and hypothesis-generating, aiming to characterise patterns across diverse populations. Our findings highlight the need for holistic, multidisciplinary, equity-focused menopause care and policy approaches beyond narrowly symptom-based models. Future research should prioritise longitudinal designs and culturally grounded approaches to better understand trajectories and inform integrated models of care.
FUNDING: NIHR Research Capability Fund.