Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
Associations between quadrant retinal layer thickness and pupillary light reflex in axial myopia.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Cao Jian, Ma Yong, Bao Yongle, Yu Yanze, Ding Xuan, Hu Jiayi, Wang Zhanying, Ye Yuhao, Zhou Xingtao, Zhao Jing
Аннотация
PURPOSE: To evaluate the impact of various factors, including sex, retinal thickness, and axial length (AL), on pupillary light reflex (PLR) in young individuals with axial myopia.
METHODS: Sixty-two patients (50% male) were recruited for this study. AL and anterior chamber metrics were measured. Ocular fundus images for quadrant retinal layer segmentation were obtained automatically using swept-source optical coherence tomography. PLR metrics, including constriction and dilation metrics (ratio, time, and velocity), were derived using the pupillometry technique.
RESULTS: Male participants showed a weaker peak pupillary constriction ratio compared with females (32.99 ± 4.85% versus 36.15 ± 5.21%, P = 0.0143). The constriction period metrics (peak ratio, time, mean velocity, and maximum velocity) showed no correlation with the AL. The maximum constriction velocity was positively affected by the ganglion cell-inner plexiform layers (GCIPL) and the entire retinal thickness in most outer annular regions (all P < 0.05). In male participants only, the peak pupil constriction ratio was affected by similar outer annular regions in the GCIPL and entire retinal thickness (all P < 0.05). The accelerated pupillary dilation time were affected by both higher AL (β=-0.256 s/mm, P = 0.038) and thicker macular retinal nerve fiber layer (mRNFL) thickness, especially in inner nasal, and outer nasal region (both P < 0.05).
CONCLUSION: Axial elongation exerts no significant impact on the constriction procedure but accelerates post-illumination dilation. Reduced outer annular GCIPL thickness is associated with attenuated pupillary constriction velocity, whereas thinning of the mRNFL in the nasal direction correlates with prolonged dilation latency.
METHODS: Sixty-two patients (50% male) were recruited for this study. AL and anterior chamber metrics were measured. Ocular fundus images for quadrant retinal layer segmentation were obtained automatically using swept-source optical coherence tomography. PLR metrics, including constriction and dilation metrics (ratio, time, and velocity), were derived using the pupillometry technique.
RESULTS: Male participants showed a weaker peak pupillary constriction ratio compared with females (32.99 ± 4.85% versus 36.15 ± 5.21%, P = 0.0143). The constriction period metrics (peak ratio, time, mean velocity, and maximum velocity) showed no correlation with the AL. The maximum constriction velocity was positively affected by the ganglion cell-inner plexiform layers (GCIPL) and the entire retinal thickness in most outer annular regions (all P < 0.05). In male participants only, the peak pupil constriction ratio was affected by similar outer annular regions in the GCIPL and entire retinal thickness (all P < 0.05). The accelerated pupillary dilation time were affected by both higher AL (β=-0.256 s/mm, P = 0.038) and thicker macular retinal nerve fiber layer (mRNFL) thickness, especially in inner nasal, and outer nasal region (both P < 0.05).
CONCLUSION: Axial elongation exerts no significant impact on the constriction procedure but accelerates post-illumination dilation. Reduced outer annular GCIPL thickness is associated with attenuated pupillary constriction velocity, whereas thinning of the mRNFL in the nasal direction correlates with prolonged dilation latency.