Oral oncology · 2023
A systematic review and meta-analysis of osteoradionecrosis following proton therapy in patients with head and neck cancer.
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Chiu Kun-Wei, Yu Tzu-Ping, Kao Yung-Shuo
Аннотация
INTRODUCTION: Head and neck cancer ranks as the seventh most common cancer worldwide. Proton therapy is widely used in head and neck cancer. Osteoradionecrosis(ORN) is currently a commonly investigated side effect of proton therapy. A meta-analysis is needed to investigate this topic.
MATERIAL/METHODS: Two authors searched three databases, including PubMed, Embase, and Cochrane Library; the search period was from inception to June 2023. The search keyword was set to be ((("osteoradionecrosis") OR ("osteonecrosis")) AND ("proton")).
RESULTS: We initially collected 410 articles, and after article selections, 22 articles remained in our systematic reviews. Due to the overlapping of patient populations, 17 studies were finally included in our meta-analysis. The pooled grade 3 or more ORN rate is 0.01(95 % CI = 0.01-0.03). Subgroup analysis showed that IMPT didn't reduce grade 3 or more ORN compared with 3DCPT (p = 0.15).
CONCLUSIONS: Our meta-analysis showed that severe ORN rarely occurred in proton therapy for head and neck cancer patients.
MATERIAL/METHODS: Two authors searched three databases, including PubMed, Embase, and Cochrane Library; the search period was from inception to June 2023. The search keyword was set to be ((("osteoradionecrosis") OR ("osteonecrosis")) AND ("proton")).
RESULTS: We initially collected 410 articles, and after article selections, 22 articles remained in our systematic reviews. Due to the overlapping of patient populations, 17 studies were finally included in our meta-analysis. The pooled grade 3 or more ORN rate is 0.01(95 % CI = 0.01-0.03). Subgroup analysis showed that IMPT didn't reduce grade 3 or more ORN compared with 3DCPT (p = 0.15).
CONCLUSIONS: Our meta-analysis showed that severe ORN rarely occurred in proton therapy for head and neck cancer patients.