The Journal of rheumatology · 2014
Common variants of cGKII/PRKG2 are not associated with gout susceptibility.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Sakiyama Masayuki, Matsuo Hirotaka, Chiba Toshinori, Nakayama Akiyoshi, Nakamura Takahiro, Shimizu Seiko, Morita Emi, Fukuda Nana, Nakashima Hiroshi, Sakurai Yutaka, Ichida Kimiyoshi, Shimizu Toru, Shinomiya Nariyoshi
Аннотация
OBJECTIVE: Recently, genetic analyses indicated the association between gout and cGMP-dependent protein kinase 2 (cGKII/PRKG2) gene in a Fukien-Taiwanese heritage population. However, no replication study has been reported in other ancestries. Therefore, we investigated this association in a Japanese population.
METHODS: Genotyping of 4 variants (rs11736177, rs10033237, rs7688672, and rs6837293) of cGKII was performed in 741 male gout patients and 1302 male controls.
RESULTS: cGKII variants have no association with gout.
CONCLUSION: Our replication study suggests that cGKII is not involved in gout susceptibility.
METHODS: Genotyping of 4 variants (rs11736177, rs10033237, rs7688672, and rs6837293) of cGKII was performed in 741 male gout patients and 1302 male controls.
RESULTS: cGKII variants have no association with gout.
CONCLUSION: Our replication study suggests that cGKII is not involved in gout susceptibility.