Pain research & management · 2026
Paraspinal Muscle Fatty Infiltration as a Predictor of Intervertebral Disc Degeneration and Pain Severity in Chronic Low Back Pain.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wang Weiyi, Wang Guanyi, Dong Jintao, Chi Simin, He Fang, Lei Xin, Chen Changchang, Luo Zhuojing, Liu Xiwen, Gao Bo
Аннотация
BACKGROUND: Chronic low back pain (CLBP) is commonly associated with paraspinal muscle fatty infiltration and intervertebral disc degeneration (IDD); however, their independent contributions to pain and disability, as well as the influence of Body Mass Index (BMI) on these associations, remain unclear.
OBJECTIVE: This study aimed to investigate the associations of paraspinal muscle fatty infiltration rate (FIR) and cross-sectional area (CSA)-specifically of the multifidus (MF), erector spinae (ES), and psoas major (PM)-with IDD severity, clinical metrics (pain (Visual Analog Scale [VAS]) and disability (Oswestry Disability Index [ODI])), and demographic factors (age, sex, and BMI) in patients with CLBP.
METHODS: A cross-sectional study included 118 CLBP patients. FIR and CSA of paraspinal muscles at L2-S1 were quantitatively measured on MRI using ImageJ. IDD was graded using the Pfirrmann system. Correlations and group comparisons were statistically analyzed.
RESULTS: FIR showed significant sex-based differences but no left-right asymmetry and was not associated with BMI. MF FIR was strongly positively correlated with Pfirrmann grade (r > 0.7, p < 0.05). FIR of MF and ES was positively correlated with age and disease duration, as well as VAS and ODI scores (r > 0.6, p < 0.05), whereas CSA showed only weak correlations. The PM exhibited minimal associations with clinical or degenerative parameters.
CONCLUSION: Paraspinal muscle fatty infiltration, especially in the MF and ES, is strongly associated with IDD severity, pain, and disability independently of BMI. FIR could serve as a potential imaging biomarker for assessing CLBP severity and progression.
OBJECTIVE: This study aimed to investigate the associations of paraspinal muscle fatty infiltration rate (FIR) and cross-sectional area (CSA)-specifically of the multifidus (MF), erector spinae (ES), and psoas major (PM)-with IDD severity, clinical metrics (pain (Visual Analog Scale [VAS]) and disability (Oswestry Disability Index [ODI])), and demographic factors (age, sex, and BMI) in patients with CLBP.
METHODS: A cross-sectional study included 118 CLBP patients. FIR and CSA of paraspinal muscles at L2-S1 were quantitatively measured on MRI using ImageJ. IDD was graded using the Pfirrmann system. Correlations and group comparisons were statistically analyzed.
RESULTS: FIR showed significant sex-based differences but no left-right asymmetry and was not associated with BMI. MF FIR was strongly positively correlated with Pfirrmann grade (r > 0.7, p < 0.05). FIR of MF and ES was positively correlated with age and disease duration, as well as VAS and ODI scores (r > 0.6, p < 0.05), whereas CSA showed only weak correlations. The PM exhibited minimal associations with clinical or degenerative parameters.
CONCLUSION: Paraspinal muscle fatty infiltration, especially in the MF and ES, is strongly associated with IDD severity, pain, and disability independently of BMI. FIR could serve as a potential imaging biomarker for assessing CLBP severity and progression.