[Anti TNF-alpha treatment of a refractory polymyositis].

INTRODUCTION

Anti TNF-alpha agents may represent a possibility of treatment in cases of refractory polymyositis.

CASE REPORT: We report a case of polymyositis refractory to corticosteroids and immunosuppressive agents in whom adjunction of infliximab led to a mild and transient improvement, and a secondary improvement after discontinuation of the treatment.

DISCUSSION: In the reported cases of polymyositis treated with infliximab or etanercept a short-term response was seen in 9 out of 11 cases. Adverse events of the treatment are mentioned, and should be taken into account in the decision of treatment.