Lessons from an early rheumatoid arthritis incident cohort.

BACKGROUND

The Canadian Early Arthritis Cohort (CATCH) study, a pioneering national registry established in 2007, has generated robust real-world evidence that has significantly advanced early rheumatoid arthritis (ERA) care in Canada and internationally.

METHODS

Data have been collected from over 3800 patients across 25 sites and >35,000 study visits.

RESULTS

This paper synthesizes 15 key learnings from CATCH that span early diagnosis, treatment strategies, patient-reported outcomes, and health equity. Findings underscore the importance of standardized data collection, early methotrexate use, and treat-to-target approaches, while also highlighting challenges such as persistent disease activity, treatment adherence, and disparities linked to sex, comorbidities, and social determinants of health. CATCH has contributed to the development and validation of novel outcome measures, supported the training of future rheumatology leaders, and informed national and international guidelines. Its infrastructure enabled continuity of research during the COVID-19 pandemic and supports pragmatic trials and innovations in care delivery.

CONCLUSIONS

As real-world incident cohort, CATCH has helped to answer questions that impact clinical and policy decisions, and CATCH exemplifies the enduring value of well-curated patient registries in generating actionable insights to improve outcomes for people living with ERA.