C-Reactive Protein for Pulmonary Tuberculosis Screening and Treatment Response Monitoring in Children.

C-reactive protein (CRP) was evaluated as a biomarker for pulmonary tuberculosis (TB) diagnosis and treatment response monitoring in 292 Kenyan children. Although diagnostic sensitivity was suboptimal (35.5%-50.0%), the median CRP level decreased during TB treatment in children with confirmed (P = .02) or unconfirmed (P < .001) TB, primarily among those with baseline CRP elevation ≥5 mg/L (40% [39 of 97]).